Evidence map›Paper›PMID 40499191›Full record

ReviewAnnual review of microbiology2025

To Sporulate or Not to Sporulate: Developmental Checkpoints Monitoring

Zachory M Park, Kumaran S Ramamurthi

Abstract readReview
In one paragraph

Review in Annual review of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zachory M ParkLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA ; email: ramamurthiks@mail.nih.gov.
Kumaran S RamamurthiLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA ; email: ramamurthiks@mail.nih.gov.

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Developmental processes are carefully regulated programs that are present in multiple kingdoms of life and that generally result in cell differentiation and specialization. This regulation can be mediated in part by checkpoints that monitor the progression of development to ensure that earlier steps occur successfully before later steps are initiated. Bacterial endospore formation (i.e., sporulation) is a well-studied developmental program that transforms a progenitor cell into a dormant cell type in response to environmental stress and that serves as a model for the discussion of checkpoint mechanisms used to monitor development. This review focuses on the checkpoints monitoring bacterial sporulation, with an emphasis on the model gram-positive bacterium

Indexed as

Bacillus subtilisGene Expression Regulation, BacterialSpores, BacterialBacterial ProteinsBacterial ProteinsBacillus anthracisC. difficilecell cycle checkpointsspore

Identifiers

PMID40499191
PMCPMC13417432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.