Evidence map›Paper›PMID 40499034›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Controlling the Helicity and Handedness of Polyaromatics with Isobenzofuranophane.

Abhijeet R Agrawal, Israa Shioukhi, Yinon Deree, Benny Bogoslavsky, Ori Shalev, Roy Hoffman, Ori Gidron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Through-bondJournal of materials chemistry. C · 2026
    Article
  3. Article
  4. Controlling the Helicity and Handedness of Polyaromatics with Isobenzofuranophane.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhijeet R AgrawalInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.
Israa ShioukhiInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.
Yinon DereeInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.
Benny BogoslavskyInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.
Ori ShalevThe Metabolic Profiling Unit, The Core Research Facility, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Roy HoffmanInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.
Ori GidronInstitute of Chemistry and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 9190401, Israel.ORCID https://orcid.org/0000-0002-7037-0563

Funding

European Union's Horizon 2020 research and innovation program 850836Israel Science Foundation 3085/21
6 · The paper itself

Abstract

The extent of helicity in nonplanar polyaromatic materials affects their electronic, optical and chiroptical properties. However, controlling helicity in different systems typically requires different multistep synthetic approaches for each target compound, often with significant complexity, thereby limiting its applicability. Here, we introduce a helical synthon, isobenzofuranophane, with either a short or long tether, which enables late-stage helicity induction and control in aromatic frameworks. We demonstrate the applicability of this synthon by reacting it with a [5]helicene aryne precursor, where both the handedness and helicene pitch are remotely-controlled by the tether length, directly affecting the (chiro)optical properties of the helicene. The X-ray structures support these findings with up to 35° torsion for a single benzene ring, demonstrating the potential of isobenzofuranophane to induce significant curvature to polyaromatic molecules.

Indexed as

ChiralityCircular dichroismCircularlyCyclophanesHelicenesTwistacenes

Identifiers

PMID40499034
PMCPMC12338401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.