SynthesisRevista do Instituto de Medicina Tropical de Sao Paulo2025
Chlamydia trachomatis infection and risk of ovarian cancer: a systematic review and meta-analysis.
Synthesis in Revista do Instituto de Medicina Tropical de Sao Paulo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Review
- Comprehensive single-cell analysis reveals cellular heterogeneity and immune interactions in colorectal cancer.Translational oncology · 2026Article
- Critical role of reproductive tract microbiota and derived metabolites in inflammation, tumor immunity, and tumorigenesis of gynecological cancers: a narrative review.Frontiers in immunology · 2026Review
- Investigating the potential causal link between BPA and ovarian carcinogenesis: a network toxicology and mendelian randomization study on the CTRC/PRDX1/SKP1 pathway.Journal of ovarian research · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlamydia trachomatis infection has been implicated as a potential risk factor for ovarian cancer (OC), but evidence remains inconclusive. This study aims to assess the association between C. trachomatis infection and OC risk using a systematic review and meta-analysis. A comprehensive literature search was conducted in PubMed, Embase, Scopus, Web of Science, and SciELO from their inception to October 2024. Observational studies examining the association between C. trachomatis infection and OC risk were included. Pooled odds ratios (ORs) were calculated using random-effects models. Subgroup and sensitivity analyses were performed based on diagnostic methods and control group types, and publication bias was assessed using Egger's test. Out of 3,288 records, 11 studies involving 4,518 participants were included. The overall meta-analysis revealed a non-significant association between C. trachomatis infection and OC risk (OR = 1.30, 95% CI = 0.99-1.70). However, sensitivity analysis excluding two studies demonstrated a significant association (OR = 1.37, 95% CI = 1.16-1.61). Subgroup analysis showed that PCR-diagnosed C. trachomatis infection was significantly associated with an increased risk (OR = 6.64, 95% CI = 1.62-25.71), while serology-based studies yielded non-significant results. Heterogeneity was high (I² = 70.83%), and publication bias was detected (Egger's test p = 0.015). These findings highlight the role of infection chronicity in OC pathogenesis and suggest that diagnostic methodology significantly impacts observed associations. Future research should employ longitudinal designs with serial molecular testing to establish temporality and evaluate whether targeted Chlamydia screening or treatment interventions could mitigate OC risk in high-prevalence populations.
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