Evidence map›Paper›PMID 40498867›Full record

ArticlePloS one2025

Pain in the brain: Psychological correlates of chronic pain and fibromyalgia.

Marcello Passarelli, Luca Rizzi, Laura Casetta, Vittorio Guerrieri, Diego Rocco, Raffaella Perrella

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Journal of medical physics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marcello PassarelliInstitute of Educational Technology, National Research Council, Genoa, Italy.ORCID 0000-0002-7991-8812
Luca RizziAssociazione Centro di Psicologia e Psicoterapia Funzionale, Padua, Italy.
Laura CasettaAssociazione Centro di Psicologia e Psicoterapia Funzionale, Padua, Italy.
Vittorio GuerrieriDepartment of Psychology, University of Milano-Bicocca, Milan, Italy.ORCID 0009-0006-7517-3039
Diego RoccoDepartment of Developmental and Social Psychology, University of Padua, Padua, Italy.
Raffaella PerrellaDepartment of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.ORCID 0000-0003-2301-2066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia is a chronic disorder causing widespread pain, fatigue, and cognitive issues, linked to central nervous system dysfunction. This cross-sectional study compared the psychological profiles of women with fibromyalgia (N = 76) and women with non-fibromyalgic chronic pain (N = 73). Using cluster analysis, scale score comparisons using MANCOVA, and correlation difference tests, we examined whether these conditions present distinct psychological profiles in terms of touch avoidance, anxiety, depression, psychotic symptoms, self-criticism, pain acceptance, pain impact, and positive emotions. Cluster analysis successfully differentiated between FM and non-FM CP patients with 76% accuracy with and an adjusted Rand index of.26, suggesting distinct psychological profiles while acknowledging substantial overlap. FM patients reported significantly higher levels of anxiety, depression, and psychotic symptoms, along with greater self-criticism and reduced activity engagement (p < .001 for all significant comparisons expect psychotic symptoms, p = .07, and opposite sex touch avoidance, p = .014). Both groups showed elevated touch avoidance, with no significant differences between them. Correlation analysis revealed that self-criticism played a more central role in FM patients' psychological distress, showing stronger associations with depression, anxiety, and positive emotions compared to non-FM CP patients (Jennrich test for differences between the two correlation matrices: Χ2 = 436.72, p < .001). These findings suggest that while FM and non-FM CP share common psychological features, FM patients experience more severe psychological distress, with self-criticism potentially playing a crucial maintaining role. Results suggest that psychological interventions for FM patients should prioritize reducing self-criticism and enhancing self-reassurance, while healthcare providers should be mindful of the significant psychological burden these patients carry.

Indexed as

BrainChronic PainFibromyalgiaAdultAnxietyCross-Sectional StudiesDepressionFemaleHumansMiddle Aged

Identifiers

PMID40498867
PMCPMC12157783

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.