Evidence map›Paper›PMID 40498845›Full record

ArticleScience advances2025

Sequential transcriptional programs underpin activation of hippocampal stem cells.

Piero Rigo, Sara Ahmed-de-Prado, Rebecca L Johnston, Chandra Choudhury, François Guillemot, Lachlan Harris

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Piero RigoNeural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-4010-5029
Sara Ahmed-de-PradoNeural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0009-0002-7845-8217
Rebecca L JohnstonQIMR Berghofer, Brisbane, QLD 4006, Australia.ORCID 0000-0001-7503-9514
Chandra ChoudhuryQIMR Berghofer, Brisbane, QLD 4006, Australia.ORCID 0000-0002-6768-991X
François GuillemotNeural Stem Cell Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.ORCID 0000-0003-0432-5067
Lachlan HarrisQIMR Berghofer, Brisbane, QLD 4006, Australia.ORCID 0000-0002-7820-0921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult neural stem cells exist on a continuum from deep to shallow quiescence that changes in response to injury or aging; however, the transcription factors controlling these stepwise transitions have not been identified. Single-cell transcriptomic analyses of mice with loss of function or increased levels of the essential activation factor

Indexed as

HippocampusNeural Stem CellsTranscription, GeneticAnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell ProliferationGene Expression ProfilingMiceSingle-Cell AnalysisTranscriptomeAscl1 protein, mouseBasic Helix-Loop-Helix Proteins

Identifiers

PMID40498845
PMCPMC12154177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.