Evidence map›Paper›PMID 40498826›Full record

ArticleScience advances2025

SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics.

Yiming Li, Yanyi Ding, Saya Dennis, Meghan R Hutch, Jiaqi Zhou, Yadi Zhou, Yawei Li, Maalavika Pillai, Sanaz Ghotbaldini, Mario Alberto Garcia and 6 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. HISSTA: a human in situ single-cell transcriptome atlas.Bioinformatics (Oxford, England) · 2025
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yiming LiDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-2111-3939
Yanyi DingDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0009-0007-1437-9719
Saya DennisDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-3887-198X
Meghan R HutchDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-8130-9429
Jiaqi ZhouDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-8225-2807
Yadi ZhouGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Yawei LiDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9699-5118
Maalavika PillaiDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-4661-1678
Sanaz GhotbaldiniDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.
Mario Alberto GarciaDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.
Mia S BroadKen and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60610, USA.ORCID 0000-0001-9199-9072
Chengsheng MaoDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-1515-9626
Parambir S DulaiDepartment of Medicine, Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9514-2321
Feixiong ChengGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Zexian ZengCenter for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.ORCID 0000-0002-3905-3244
Yuan LuoDepartment of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-0195-7456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial transcriptomics enables multiplex profiling of gene cellular expression and location within the tissue context. Although large volumes of spatial transcriptomics data have been generated, the lack of systematic curation and analysis limits biological discovery. We present Spatial transcriptOmics Analysis Resource (SOAR), a comprehensive spatial transcriptomics platform with 3461 uniformly processed samples across 13 species, 42 tissue types, and 19 different spatial transcriptomics technologies. Using SOAR, we found that

Indexed as

Drug DiscoveryGene Expression ProfilingTranscriptomeAnimalsHumansHydroxamic AcidsMacrophagesSignal TransductionSirolimusTumor MicroenvironmentHydroxamic AcidsSirolimustrichostatin A

Identifiers

PMID40498826
PMCPMC13109963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.