ArticlePloS one2025
Atherosclerosis is associated with amyloid and tau pathology via blood-brain barrier dysfunction in the hippocampus of aged human brains.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Opposite molecular sex correlations in tauopathy paralleled by motor and cognitive efficacy of davunetide in women.Molecular psychiatry · 2026Article
- Hypothalamic wars: the last nanodelivery.Reviews in endocrine & metabolic disorders · 2026Review
- Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer's disease.Nature communications · 2025Article
- Relationship of the TG/HDL Ratio With Cognition Function in Older Adults (≥ 60 Years): A Cross-Sectional Analysis of NHANES 2011-2014.Health science reports · 2025Article
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Authors and funding
3 authors.
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Abstract
Atherosclerosis, a chronic vascular condition characterized by lipid accumulation and arterial plaque formation, has emerged as a significant contributor to neurodegenerative diseases, including Alzheimer's disease (AD). This study investigated the association between severe atherosclerosis and hippocampal changes in aged human brains, focusing on blood-brain barrier (BBB) dysfunction and its potential role in amyloid-beta (Aβ) and phosphorylated tau (pTau) pathology. Using multiplex immunohistochemical staining of postmortem brain tissue, we demonstrated that atherosclerosis-associated vascular damage leads to endothelial and smooth muscle cell apoptosis, exacerbates cerebral amyloid angiopathy (CAA), and promotes perivascular tau accumulation. These findings highlight a potential association between vascular health and neurodegeneration, offering insights into potential therapeutic targets for mitigating AD progression.
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