ArticlePloS one2025
L-shaped association between the blood pressure response index and short-term mortality in intensive care patients with sepsis: An analysis based on the MIMIC-IV database.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Group-based trajectory modeling of blood pressure reactivity and mortality in septic patients: a retrospective study of the MIMIC-IV database.BMC infectious diseases · 2026Article
- Early blood pressure response index and mortality risk in cardiogenic shock: evidence from two critical care cohorts.BMC cardiovascular disorders · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic shock is a life-threatening condition that requires rapid assessment to reduce mortality. This study investigated the relationship between the blood pressure response index at admission and short-term mortality in septic shock patients.
methodsWe retrospectively analyzed clinical data from the MIMIC-IV database via multivariable logistic regression, sensitivity analysis, and restricted cubic spline models to explore the associations between the BPRI at ICU admission and short-term mortality. Kaplan-Meier estimates and ROC curves evaluated BPRI's predictive value.
resultsIn 7,382 patients, a higher BPRI was linked to reduced short-term mortality. Each standard deviation increase in the BPRI led to 2.5%, 2.0%, and 1.8% reductions in in-hospital, 28-day, and 90-day mortality, respectively. K‒M analysis revealed significantly lower short-term mortality in patients with higher BPRIs (P < 0.0001). An L-shaped nonlinear relationship between the BPRI and mortality was observed in the RCS model. The ROC curve for the BPRI showed an AUC of 0.640. Sensitivity analyses revealed an association even after patients with myocardial infarction, malignant cancer, or missing data were excluded.
conclusionAn elevated BPRI at ICU admission is significantly associated with reduced short-term mortality in septic shock patients, indicating its potential as an early prognostic tool for risk assessment.
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