ArticlePloS one2025
Global burden of knee osteoarthritis from 1990 to 2021: Trends, inequalities, and projections to 2035.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Telerehabilitation intervention after total knee arthroplasty in Iran: a feasibility and acceptability randomised controlled trial.BMJ open · 2026Trial
- The psychometric properties of Functional Gait Assessment (FGA) in assessing walking ability in people with knee osteoarthritis.Journal of exercise science and fitness · 2026Article
- Radiological and Clinical Evaluation of the Ipsilateral Ankle of Patients Who Underwent Total Knee Arthroplasty: A Prospective Study.Journal of clinical medicine · 2026Article
- Adipose-cartilage communication via EV-Mito-mtDNA signaling promotes osteoarthritis progression.Science advances · 2026Article
- Decoction-derived bioactive nanoparticles of Lycopodium japonicum Thunb. attenuate knee osteoarthritis by regulating MAPK/ERK signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Predicting kinesiophobia in knee osteoarthritis: a head-to-head comparison between machine learning and traditional regression models.BMC musculoskeletal disorders · 2026Article
- Association of latent class trajectories of frailty with incident symptomatic knee osteoarthritis in Chinese postmenopausal women: a nationwide cohort study from China.Scientific reports · 2026Article
- Human adipose-derived mesenchymal stromal cells in vitro expansion for regenerative applications: tracking small genetic variants reveals dynamic changes within a genetically stable framework.Stem cell research & therapy · 2026Article
- Exosomes and Small Extracellular Vesicles as an Alternative to Mesenchymal Stromal Cell Therapy in Knee Osteoarthritis: From Biological Rationale to Clinical Evidence.International journal of molecular sciences · 2026Review
- Current trends and projections for potential acupuncture needs globally and in China: evidence from the Global Burden of Disease Study 2021.Chinese medicine · 2026Article
- Current status and influencing factors of early delayed neurocognitive recovery in older adult patients after major orthopedic surgery under general anesthesia: a cohort study.Frontiers in public health · 2026Observational
- Metabolic pathways linking air pollution to osteoarthritis: Insights from a prospective cohort.PloS one · 2026Article
- Tracking global quality of life trajectories in knee osteoarthritis: a population-based long-term analysis.Therapeutic advances in musculoskeletal disease · 2026Article
- The global profile of individuals undergoing total knee replacement surgery through a PROGRESS-PLUS equity lens: A systematic review.The South African journal of physiotherapy · 2026Review
- Phenotype-informed management of preoperative asymptomatic isolated muscular calf vein thrombosis in patients undergoing primary total knee arthroplasty under standardized thromboprophylaxis: a retrospective cohort study.Frontiers in medicine · 2026Article
- [Analysis of current status and trends of disease burden of knee osteoarthritis in China, 1990-2023].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- Global burden of athletic-type knee dislocation in young adults: a GBD 2021 proxy-based analysis, 1990-2021.Frontiers in physiology · 2025Article
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10 authors.
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Abstract
introductionTo present the global, regional, and national burden of knee osteoarthritis (KOA) and its causative factors, categorized by age, gender, and sociodemographic indices from 1990 to 2021, and to project future trends to 2035.
methodsA comprehensive analysis of KOA epidemiology was conducted using data from the 2021 Global Burden of Disease Study (GBD). The study examined change trends in KOA burden between 1990 and 2021, including prevalence, incidence, disability-adjusted life years (DALYs), and associated risk factors. Health inequality analyses were performed using slope index of inequality (SII) and concentration index (CI). Decomposition analysis was conducted to understand the contributions of population growth, aging, and epidemiological changes to the increasing burden. Future projections were made for global, Chinese, and Indian trends to 2035.
resultsIn 2021, the global prevalence of KOA was 374.7 million cases, with an annual incidence of 3.0846 million cases, totaling 12.01 million DALYs. Age-standardized rates for prevalence, incidence, and DALYs increased by 8.3%, 7.1%, and 8.2% respectively since 1990. Health inequality analyses revealed widening disparities across SDI levels, with SII for crude incidence rates increasing from 251 to 400 per 100,000 between 1990 and 2021. Decomposition analysis showed population growth as the primary driver of increased burden globally (75.07% for DALYs), with variations across SDI regions. Projections to 2035 indicate substantial increases in global burden, with incidence expected to rise by 33.6%, prevalence by 43.8%, and DALYs by 41.4%. China and India show differing patterns in projected burden increases.
conclusionKOA remains a significant public health concern with increasing burden and widening health inequalities. The projected increases highlight the need for targeted interventions, especially in rapidly growing populations. Preventive measures should focus on reducing high BMI, implementing gender-specific treatments, and addressing regional disparities to mitigate the future burden of KOA.
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