ArticlePLOS digital health2025
The impact of mind-body internet and mobile-based interventions on fatigue in adults living with chronic physical conditions: A systematic review and meta-analysis of randomized controlled trials.
Article in PLOS digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial.PLoS medicine · 2026Trial
- Integrative Hepatology: Enhancing overall health to manage liver disease.Hepatology (Baltimore, Md.) · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic physical conditions (CPCs) are conditions that persist for long periods and may not have a cure. Fatigue is a common symptom experienced by people living with CPCs. Mind-body internet and mobile-based interventions (IMIs) offer an accessible management strategy. The objective of this review was to assess the impact of mind-body IMIs on fatigue symptoms in adults with CPCs. Six databases were searched from inception to July 2024. Inclusion required randomized controlled trials (RCTs) of mind-body IMIs in adults (≥ 18) with CPCs that assessed fatigue pre-and post-intervention using self-report questionnaires. The primary outcome was the standardized mean fatigue change scores (Hedges' g). Sub-group analyses were conducted on CPC type, mind-body technique, fatigue questionnaire, and personnel support level. Meta-regression was performed on IMI length and age. Study quality was assessed using the Cochrane Risk of Bias 2.0 tool. The search retrieved 5239 studies. Seventeen studies met inclusion criteria: 47% neurological (n = 8), 29% cancer (n = 5), and 24% autoimmune (n = 4). Seven studies (41%) included cognitive behavioural therapy (CBT), seven used CBT combined with non-CBT techniques, and three employed non-CBT techniques. Mind-body IMIs led to significant reductions in fatigue (SMD = -0.74 [-1.09, -0.39]; p < 0.0001), with a greater effect in younger participants (p = 0.005). Heterogeneity was moderate to high. In conclusion, mind-body IMIs show promise in reducing fatigue symptoms in adults with CPCs. Further high-quality RCTs, expanding beyond CBT techniques, and using at least one common fatigue scale across conditions, would be helpful in evaluating the impact of IMIs across a broader range of CPCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.