Evidence map›Paper›PMID 40498718›Full record

ArticlePLoS biology2025

Condensate dynamics at the synapse: Phase separation tunes presynaptic function.

Janine Lützkendorf, Stephan J Sigrist

Abstract readComment
In one paragraph

Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Janine LützkendorfFreie University Berlin, Institute for Biology and Genetics, Berlin, Germany.ORCID 0000-0001-5051-6281
Stephan J SigristFreie University Berlin, Institute for Biology and Genetics, Berlin, Germany.ORCID 0000-0002-1698-5815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics.

Indexed as

Presynaptic TerminalsSynapsesAnimalsPhase SeparationSynaptic TransmissionSynaptic Vesicles

Identifiers

PMID40498718
PMCPMC12157082

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.