Evidence map›Paper›PMID 40498633›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Post-COPD: Can Emphysema Be Repaired?

J Michael Wells, Jerry A Krishnan, R Chad Wade, Greg Kinney, Robert A Wise, Enid Neptune, Francesca Polverino, Nicola A Hanania, Matthew Moll, Melanie Königshoff and 14 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Investigating human lung resilience, its evolutionary history and its relation to COPD.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

J Michael WellsDivision of Pulmonary, Allergy, and Critical Care Medicine and.ORCID 0000-0001-9612-5454
Jerry A KrishnanBreathe Chicago Center, Division of Pulmonary, Critical Care, Sleep, and Allergy, and.ORCID 0000-0001-5525-4778
R Chad WadeDivision of Pulmonary, Allergy, and Critical Care Medicine and.ORCID 0000-0001-7771-9855
Greg KinneyDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Robert A WiseSchool of Medicine and.ORCID 0000-0002-8353-2349
Enid NeptuneSchool of Medicine and.
Francesca PolverinoSection of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
Nicola A HananiaSection of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, Texas.
Matthew MollChanning Division of Network Medicine.
Melanie KönigshoffDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-9414-5128
Divay ChandraDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Frank SciurbaDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Nathaniel MarchettiDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
Raúl San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-3677-1996
Alejandro A DiazDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0001-5037-2919
Karim El-KershDivision of Pulmonary and Critical Care Medicine, University of Arizona College of Medicine, Phoenix, Arizona.
Mario CastroDivision of Pulmonary, Critical Care and Sleep Medicine, University of Kansas Medical Center, Kansas City, Kansas.ORCID 0000-0001-6328-8994
Ying ZhangDepartment of Biostatistics, College of Public Health, and.
Janet T HolbrookCenter for Clinical Trials and Evidence Synthesis, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Elizabeth A SugarCenter for Clinical Trials and Evidence Synthesis, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Monica KraftDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Robert J KanerDivision of Pulmonary and Critical Care Medicine and.
Barry MakeDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado.
Stephen RennardDivision of Pulmonary, Critical and Sleep Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.

Funding

Clinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2M
Understanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7M
Clinical implications and Proteomics of Bronchiectasis Progression in SmokersR01HL173017 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Alejandro Diaz, Raul San Jose Estepar · 2024 to 2026
$2.6M
Matrikines and COPD-PHR01HL148215 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WELLS, JAMES MICHAEL · 2019 to 2023
$2.4M
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolismR01HL171622 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Francesca Polverino · 2024 to 2026
$2.2M
Non-canonical WNT signaling in emphysema and lung regenerationR01HL141380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOENIGSHOFF, MELANIE · 2019 to 2022
$2.1M
NHLBI NIH HHS R01 HL141380NHLBI NIH HHS R01 HL148215NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL164824NHLBI NIH HHS R01 HL171622NHLBI NIH HHS R01 HL173017
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40498633
PMCPMC12756936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.