ArticleProceedings of the National Academy of Sciences of the United States of America2025
Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of
Lahari Das, Bing Chen, Saranathan Rajagopalan, Catherine Vilcheze, Claire V Mulholland, Michael Berney, Patrick K Andrews, Ashley Edwards, Ramanuj Lahiri, William R Jacobs
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Lahari DasDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Bing ChenDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Saranathan RajagopalanDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Catherine VilchezeDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Claire V MulhollandDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.
Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-4833-0573
Patrick K AndrewsUnited States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA 70816.
Ashley EdwardsUnited States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA 70816.
Ramanuj LahiriUnited States Department of Health and Human Services, Health Resources and Services Administration, Health Systems Bureau, National Hansen's Disease Program, Baton Rouge, LA 70816.
William R JacobsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-3321-3080
Funding
Molecular Genetic Analysis of Mycobacterium TuberculosisR37AI026170 · NIAID · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI WILLIAM Robert JACOBS · 2004 to 2026
$7.7M
Rapid phenotypic detection of complex and emergent TB drug-resistance using a next-generation nanoluciferase reporter phageR01AI176407 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Max O'Donnell · 2023 to 2026
$3.0M
The PDIM paradox of M. tuberculosisR01AI175972 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.0M
IVIS SpectrumCTS10OD034192 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI WEISS, LOUIS M. · 2024 to 2024
$599k
Genetic engineering of Mycobacterium leprae to Glow and GrowR21AI168785 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JACOBS, WILLIAM ROBERT · 2022 to 2023
$462k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) NIAID/HRSA AAI23014-001-00000HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) 1R01AI176407-01HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) R21AI68785HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) R37AI026170-37NIAID NIH HHS R01 AI175972NIAID NIH HHS R01 AI176407NIAID NIH HHS R21 AI168785NIAID NIH HHS R37 AI026170NIH HHS S10 OD034192
6 · The paper itself
Abstract
PubMed holds no abstract for this paper.
Indexed as
Gene Transfer TechniquesLeprostatic AgentsLeprosyMycobacteriophagesMycobacterium lepraeAnimalsDapsoneDrug Evaluation, PreclinicalFemaleGenes, ReporterLuciferasesMiceRifampinDapsoneLeprostatic AgentsLuciferasesRifampindrug susceptibilityin vivo imagingmycobacteriophageMycobacterium leprae
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of · full record | OpenQuestion