ArticleMetabolomics : Official journal of the Metabolomic Society2025
Assessing metabolic alterations and cancer biomarkers in athymic nude mice implanted with NSCLC spheroids.
Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPreclinical rodent models are vital in cancer research, and enhancing their relevance reduces animal use.
aimThe aim of this pilot study was to determine if A549 lung cancer spheroids implanted into athymic nude mice will change the serum metabolite profile and express serum cancer biomarkers.
methodSpheroid non-small cell carcinoma tumours were implanted into athymic nude mice.
resultsTumours produced significant levels of selected serum cancer biomarkers, and the implanted tumours had changed the serum metabolite profiles-mimicking human lung cancer profiles-which were significantly different from the non-cancer control. Histological analysis confirmed characteristics of solid adenocarcinomas.
conclusionThe A549 spheroid-derived xenograft model demonstrates promise as a feasible and physiologically relevant tool for non-small cell lung cancer research.
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