Evidence map›Paper›PMID 40498289›Full record

ArticleEuropean journal of immunology2025

Identification and Mapping of Human Lymph Node Stromal Cell Subsets by Combining Single-Cell RNA Sequencing with Spatial Transcriptomics.

Cristoforo Grasso, Janna E G Roet, Catarina Gago de Graça, Johanna F Semmelink, Michael de Kok, Ester Remmerswaal, Aldo Jongejan, Perry D Moerland, Reina E Mebius, Lisa G M van Baarsen

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristoforo GrassoDepartment of Rheumatology and Clinical Immunology, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-6605-6910
Janna E G RoetAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Catarina Gago de GraçaAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Johanna F SemmelinkDepartment of Rheumatology and Clinical Immunology, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Michael de KokAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Ester RemmerswaalDepartment of Experimental Immunology, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, the Netherlands.
Aldo JongejanAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Perry D MoerlandAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Reina E MebiusAmsterdam Institute for Immunology and Infectious Diseases, Amsterdam, the Netherlands.
Lisa G M van BaarsenDepartment of Rheumatology and Clinical Immunology, Amsterdam UMC, location AMC, University of Amsterdam, Amsterdam, the Netherlands.

Funding

ZonMw 91718371ZonMw TOP 01217014
6 · The paper itself

Abstract

Lymph node stromal cells (LNSCs) have a crucial immunomodulatory function, but their heterogeneity in humans is incompletely understood. Here, we report the single-cell RNA sequencing (scRNA-seq) of 9267 LNSCs isolated from a human lymph node (LN). This study comprehensively defines the gene signatures of 10 fibroblast subtypes: CCL21

Indexed as

Lymph NodesStromal CellsTranscriptomeFemaleGene Expression ProfilingHumansMaleSequence Analysis, RNASingle-Cell Analysisfibroblasthumanlymph node stromal cellssingle‐cell RNA sequencingspatial transcriptomicsstroma‐immune system

Identifiers

PMID40498289
PMCPMC12154172

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.