Evidence map›Paper›PMID 40498235›Full record

ReviewInflammopharmacology2025

Progress on the mechanism of natural polysaccharides in the treatment of arthritis.

Lili Yuan, Michael Adu-Frimpong, Hong Chen, Yaping Yang, Jiangnan Yu, Huiya Wang, Yuxiang He, Elmurat Toreniyazov, Xia Cao, Qilong Wang and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lili YuanDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.ORCID http://orcid.org/0009-0002-5865-0973
Michael Adu-FrimpongDepartment of Biochemistry and Forensic Sciences, School Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences (CKT-UTAS), UK 0215-5321, Navrongo, Ghana.
Hong ChenDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.
Yaping YangDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.
Jiangnan YuDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.
Huiya WangDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.
Yuxiang HeDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China.
Elmurat ToreniyazovTashkent State Agricultural University (Nukus Branch), Nukus, Uzbekistan.
Xia CaoDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China. caoxiaemail@163.com.
Qilong WangDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China. 294353201@qq.com.
Ximing XuDepartment of Pharmacy, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University, Zhenjiang, Jiangsu, China. xmxu@ujs.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81720108030Innovative Research Group Project of the National Natural Science Foundation of China 8217131836Innovative Research Group Project of the National Natural Science Foundation of China 82173785The Special Foundation for Basic Research Program of Zhenjiang JC2024013
6 · The paper itself

Abstract

Arthritis is a common joint-injury disease, and because its exact etiology and pathogenesis remain incompletely understood, current treatment options for it are highly limited. Conventional treatments focus on anti-inflammatory drugs to alleviate the disease. However, long-term use of these medications can cause increasingly serious side effects. Therefore, there is an urgent need to develop safe and effective anti-arthritis drugs with fewer side effects. Polysaccharides derived from natural products have received a lot of attention because of their safety and multiple active effects, wherein they have shown strong potential especially in the treatment of arthritis. However, a systematic presentation of polysaccharides against arthritis is still lacking. In this paper, we summarize the recent studies on natural polysaccharides for arthritis treatment mainly in terms of isolation, structure-anti-arthritic relationship, pharmacokinetics, mechanisms, and association of polysaccharides with other substances. It is helpful for researchers to fully understand the anti-arthritic effects of polysaccharides and provide some references for the development and application of polysaccharides in arthritis treatment.

Indexed as

Anti-Inflammatory AgentsArthritisBiological ProductsPolysaccharidesAnimalsHumansAnti-Inflammatory AgentsBiological ProductsPolysaccharidesArthritisMechanismsPolysaccharidesStructure–anti-arthritic relationship

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.