Evidence map›Paper›PMID 40498192›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

LC-MS-Based Metabolic Fingerprinting of Vitreous Humor.

Karolina Pietrowska, Diana Anna Dmuchowska, Joanna Godzien, Joanna Konopinska, Adam Kretowski, Michal Ciborowski

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karolina PietrowskaMetabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Diana Anna DmuchowskaDepartment of Ophthalmology, Medical University of Bialystok, Bialystok, Poland.
Joanna GodzienMetabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Joanna KonopinskaDepartment of Ophthalmology, Medical University of Bialystok, Bialystok, Poland.
Adam KretowskiMetabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
Michal CiborowskiMetabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland. michal.ciborowski@umb.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitreous humor (VH) is the largest structure in the eye that fills the space between the lens and the retina. Its composition and level of metabolites may reflect the physiological and pathophysiological processes occurring in the retina. A protocol for the preparation of VH samples for untargeted metabolomics was developed, and extracted metabolites were analyzed using liquid chromatography-quadrupole-time of flight-mass spectrometry (LC-QTOF-MS). Two types of chromatography were combined with mass spectrometry, reversed-phase (RP-LC-MS), and hydrophilic interaction (HILIC-LC-MS).

Indexed as

Mass SpectrometryMetabolomeMetabolomicsVitreous BodyChromatography, LiquidHumansHydrophobic and Hydrophilic InteractionsLiquid Chromatography-Mass SpectrometryHILIC chromatographyLC–MSReversed-phase chromatographyUntargeted metabolomicsVitreous humor

Identifiers

PMID40498192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.