Evidence map›Paper›PMID 40498188›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Polyamine Metabolism in Optic Nerve: Spatial Metabolomics with AP/MALDI Mass Spectrometry Imaging.

Sean Meehan, Caleigh O'Connor, Eugene Moskovets, Konstantin Novoselov, Nivedita Bhattacharya, Sanjoy K Bhattacharya

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sean MeehanBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Caleigh O'ConnorMassTech Inc., Columbia, MD, USA.
Eugene MoskovetsMassTech Inc., Columbia, MD, USA.
Konstantin NovoselovMassTech Inc., Columbia, MD, USA.
Nivedita BhattacharyaMassTech Inc., Columbia, MD, USA.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA. SBhattacharya@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is widely recognized as a leading method for studying spatial omics. Spatial multiomics platforms are most effective when they integrate multimodal datasets to provide a comprehensive understanding of biological contexts. By combining approaches like metabolomics and lipidomics, the throughput of spatial analysis methods can be significantly enhanced. In this particular protocol, polyamine pathway-related metabolites and lipids from a mouse optic nerve are imaged using atmospheric pressure MALDI.

Indexed as

MetabolomicsOptic NervePolyaminesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAnimalsLipidomicsMicePolyaminesamino acidAP/MALDILipidsMass spectrometry imagingOCT-embedded tissueOcular neurodegenerative disordersPolyamines

Identifiers

PMID40498188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.