Evidence map›Paper›PMID 40498185›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Pathway Analysis Utilizing Metabolomic and Proteomic Datasets.

Guoqiang Zhu, Molly Kennedy, Sanjoy K Bhattacharya

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guoqiang ZhuBascom Palmer Eye Institute, Miami, FL, USA.
Molly KennedyBascom Palmer Eye Institute, Miami, FL, USA.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, Miami, FL, USA. SBhattacharya@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathway analysis of metabolomic and proteomic data is critical for understanding the intricacies of biological processes and disease mechanisms. The challenging process of pathway analysis has become less burdensome thanks to online tools and databases that enable the comparison of pathways in intricate biological systems. Data analysis tools, like MetaboAnalyst 6.0, evaluate complex interactions and metabolic networks in biological pathways. Metabolomic and proteomic data integration is performed by utilizing databases, like KEGG, to analyze pathways and determine the interplay of proteins, metabolites, and other molecules in common pathways. Molecular interactions and similarities between pathways are explored to promote hypothesis generation and guide further research. This comprehensive chapter will enhance the understanding of utilizing pathway analysis of metabolic and proteomic data of various conditions, biomarkers, organisms, and therapeutic molecular targets, paving the way for future investigations and clinical applications, especially in pharmacology. Drugs like Metformin can be studied more extensively with pathway analysis, as demonstrated in this chapter, to enhance our understanding of how drugs affect patients.

Indexed as

Computational BiologyMetabolic Networks and PathwaysMetabolomeMetabolomicsProteomicsDatabases, FactualHumansSoftwareCompound discovererMetaboAnalystMetabolomicsPathway analysisProteome discovererProteomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.