Evidence map›Paper›PMID 40498182›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Chromatographic Choice in Cerebrospinal Fluid Metabolomics Identification Outcome : Metabolomics for Cerebrospinal Fluid.

Sofía C Ayala Rodríguez, Alyssa M Suarez, Victor M Lu, Sanjoy K Bhattacharya, Ashish H Shah

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Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sofía C Ayala RodríguezBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami Integrative Metabolomics Research Center, Miami, FL, USA.
Alyssa M SuarezBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami Integrative Metabolomics Research Center, Miami, FL, USA.
Victor M LuDepartment of Neurosurgery, University of Miami School of Medicine, Miami, FL, USA.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami Integrative Metabolomics Research Center, Miami, FL, USA.
Ashish H ShahDepartment of Neurosurgery, University of Miami School of Medicine, Miami, FL, USA. AShah@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited literature on the optimal chromatographic method for cerebrospinal fluid (CSF) extraction and identification is available. Ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) is an extensively used tool in metabolic profiling because of its high resolving power, analysis sensitivity, and selectivity. This technique allows for reliable structural elucidation for metabolite identification and quantification at low micromolar to nanomolar concentration levels. In this book chapter, we discuss two complementary UPLC-MS methods, reversed-phase (RP) and chromatography hydrophilic interaction liquid chromatography (HILIC), to characterize metabolomic analysis of CSF samples.

Indexed as

Cerebrospinal FluidMetabolomeMetabolomicsChromatography, High Pressure LiquidChromatography, LiquidChromatography, Reverse-PhaseHumansHydrophobic and Hydrophilic InteractionsMass SpectrometryCerebrospinal fluidHydrophilic interaction liquid chromatographyMetabolomicsReversed-phase C18Ultraperformance liquid chromatography-mass spectrometry

Identifiers

PMID40498182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.