SynthesisLangenbeck's archives of surgery2025
Systematic review and meta-analysis of diagnostic accuracy of one-step nucleic acid amplification for lymph node metastases of papillary thyroid carcinoma.
Synthesis in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic accuracy and detection rate of lymph node metastases (LNM) in Papillary Thyroid Carcinoma (PTC) using the One-Step Nucleic Acid Amplification (OSNA) technique compared to conventional pathological methods.
methodsA systematic search was conducted in PubMed, The Cochrane Library, Scopus, and Web of Science from May 1, 2023, to June 30, 2023, for studies published from January 1, 2005, to April 30, 2023. Observational studies assessing OSNA for LNM in PTC patients were included. Two independent reviewers performed study selection, record screening, data extraction, and quality assessment using QUADAS-2. Meta-analysis was conducted with Posit software (RStudio).
resultsSeven studies (2014-2021) involving 1,424 lymph nodes from 207 PTC patients were analyzed. The pooled sensitivity, specificity, and AUC of OSNA for detecting LNM were 0.905 (95% CI 0.838-0.946), 0.884 (95% CI 0.834-0.921), and 0.848, respectively. DISCUSSION: OSNA shows promising diagnostic accuracy compared to conventional pathological methods, with the potential to improve real-time lymphatic staging and aid intraoperative decision-making. Limitations include study heterogeneity and a lack of randomized controlled trials, affecting generalizability. Further research is needed to validate the long-term benefits of OSNA in clinical practice.
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