SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Intra-articular injections of platelet-rich plasma combined with hyaluronic acid versus platelet-rich plasma alone in the treatment of knee osteoarthritis: a systematic review and meta-analysis.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Integrated Multiomics Analysis Identifies CDO1 as a Novel Therapeutic Target for OsteoarthritisEndocrine, metabolic & immune disorders drug targets · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PURPOSE/
aimThis study aimed to evaluate the efficacy and safety of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) compared to PRP alone in treating knee osteoarthritis (OA). METHODOLOGY: A systematic review and meta-analysis were conducted according to the 2020 Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. PubMed, Scopus, and Cochrane Library databases were searched for studies comparing PRP + HA to PRP alone in knee OA patients. Data on patient-reported outcomes, adverse events, and study quality were extracted.
resultsNine studies (n = 868 knees) met inclusion criteria. PRP + HA statistically significantly improved The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function, and total scores compared to PRP alone (p < 0.05), though differences were below the minimal clinically important difference (MCID). No significant differences were found in WOMAC pain, stiffness, visual analog scale (VAS) for pain, or Knee Injury and Osteoarthritis Outcome score (KOOS) between groups. Adverse events were more frequent in the PRP group (24.6%) than the PRP + HA group (15.4%), with all events being minor and self-limiting.
conclusionThere were no statistically significant differences between intra-articular PRP combined with HA and PRP alone in terms of WOMAC for pain and stiffness, VAS for pain, and KOOS. However, the combination therapy resulted in statistically significant lower WOMAC scores for physical function and total compared to PRP alone, though the differences were minimal and below the MCID.
Indexed as
Identifiers
40498171What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.