Evidence map›Paper›PMID 40498105›Full record

ArticleACS chemical neuroscience2025

The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson's Disease Experimental Models: Implications for ER Stress and Autophagy Modulation.

Zhi-Hong Wen, Ya-Jen Chiu, San-Nan Yang, Bo-Lin Guo, Chien-Wei Feng, Jimmy Ming-Jung Chunag, Nan-Fu Chen, Wu-Fu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhi-Hong WenDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.ORCID 0000-0003-4411-044X
Ya-Jen ChiuDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
San-Nan YangDepartment of Pediatrics, E-DA Hospital, School of Medicine, College of Medicine I-Shou University, Kaohsiung 82445, Taiwan.
Bo-Lin GuoDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.
Chien-Wei FengDepartment of Obstetrics aned Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.
Jimmy Ming-Jung ChunagDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833301, Taiwan.
Nan-Fu ChenDivision of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
Wu-Fu ChenDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of Parkinson's disease (PD) involves cellular processes such as endoplasmic reticulum (ER) stress, unfolded protein response, autophagy imbalance, and apoptosis, and identifying drugs that can regulate these molecular mechanisms may be a potential therapeutic strategy for PD. This study aimed to investigate the potential neuroprotective effects of the marine crinoid-derived natural compound (+)-rhodoptilometrin (RDM). We utilized an

Indexed as

AutophagyEndoplasmic Reticulum StressNeuroprotective AgentsAnimalsApoptosisCell Line, TumorCell SurvivalDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPHumansMaleMiceOxidopamineZebrafishEndoplasmic Reticulum Chaperone BiPHSPA5 protein, humanHspa5 protein, mouseNeuroprotective AgentsOxidopamine6-OHDAautophagyER stressneuroprotectionParkinson’s diseaserhodoptilometrin

Identifiers

PMID40498105
PMCPMC12232297

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.