Evidence map›Paper›PMID 40498057›Full record

ArticleAnnals of the Royal College of Surgeons of England2026

Opening the operating theatre to oncology: treatment of locally recurrent rectal cancer with peritoneal metastasis by simultaneous hyperthermic intraperitoneal chemotherapy and intraoperative electron beam radiotherapy.

Y Salem, C T West, M West, S Jain, H Yano, J Smith, C Green, A Bateman, A Mirnezami

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the Royal College of Surgeons of England, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prospective case-control cohort analysis of two-day/two-stage pelvic exenteration surgery: Safety, feasibility, acceptability and medium-term outcomes.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Y SalemUniversity Hospital Southampton NHS Foundation Trust, UK.
C T WestUniversity Hospital Southampton NHS Foundation Trust, UK.
M WestUniversity Hospital Southampton NHS Foundation Trust, UK.
S JainUniversity Hospital Southampton NHS Foundation Trust, UK.
H YanoUniversity Hospital Southampton NHS Foundation Trust, UK.
J SmithUniversity Hospital Southampton NHS Foundation Trust, UK.
C GreenUniversity Hospital Southampton NHS Foundation Trust, UK.
A BatemanUniversity Hospital Southampton NHS Foundation Trust, UK.
A MirnezamiUniversity Hospital Southampton NHS Foundation Trust, UK.ORCID 0000-0002-6199-8332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in multimodality therapies and surgical technique, locally recurrent rectal cancers (LRRC) and those with peritoneal metastasis (PM) remain challenging for surgeons and oncologists. Although total pelvic exenteration (TPE) and cytoreductive surgery (CRS) for peritoneal disease may enable removal of the main tumour mass and macroscopically visible peritoneal spread, respectively, local recurrence from an R1 resection, and peritoneal recurrence from microscopic peritoneal disease, remain key concerns. Combining radical surgery with oncological adjuncts such as intraoperative electron beam radiotherapy (IOERT), and hyperthermic intraperitoneal chemotherapy (HIPEC), may improve outcomes in this field. Nevertheless the application of both together is poorly reported. Here we describe a case of LRRC with PM treated with TPE and simultaneous HIPEC and IOERT.

Indexed as

AdenocarcinomaHyperthermic Intraperitoneal ChemotherapyNeoplasm Recurrence, LocalPeritoneal NeoplasmsRectal NeoplasmsCombined Modality TherapyCytoreduction Surgical ProceduresElectronsHumansIntraoperative CareMaleMiddle AgedOperating RoomsPelvic ExenterationCRS–HIPECIOERTLocally recurrent rectal cancerPeritoneal metastasisTotal pelvic exenteration

Identifiers

PMID40498057
PMCPMC12949691

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.