ReviewCells2025
Rosmarinic Acid as Bioactive Compound: Molecular and Physiological Aspects of Biosynthesis with Future Perspectives.
Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Unlocking the Potential ofFoods (Basel, Switzerland) · 2026Review
- Enhancement of rosmarinic acid biosynthesis in Ocimum basilicum L. via melatonin-loaded nanoparticles: insights into enzymatic activity and gene expression.BMC plant biology · 2026Article
- Rosmarinic Acid Alleviates Cisplatin-Induced Acute Kidney Injury by Targeting FYN to Regulate Ferroptosis.Food science & nutrition · 2026Article
- Green and Energy-Efficient Post-Harvest Enhancement: Low-DoseAntioxidants (Basel, Switzerland) · 2026Article
- Scale-Up Transformed Shoot and Hairy Root Cultures ofMolecules (Basel, Switzerland) · 2026Article
- Article
- Lavandin cell extract enriched in rosmarinic acid attenuates inflammation via AMPK/Nrf2/HO-1 activation and IKK/IκB/NF-κB inhibition.BMC plant biology · 2026Article
- Biologically Active Compounds and Antioxidant and DNA-Protective Potential of Rhodope AvensMolecules (Basel, Switzerland) · 2026Article
- Salicylic Acid-Induced Elicitation of Nepetalactone and Rosmarinic Acid Biosynthesis in Naked Catmint (International journal of molecular sciences · 2026Article
- Review
- Genome-Wide Identification and Expression Analysis of the Dof Transcription Factor Family inInternational journal of molecular sciences · 2026Article
- Wound Healing Potential of the Salvianolic Acid H and Yunnaneic Acid B-The Rosmarinic Acid Derivatives: Anti-Inflammatory Action and Hemocompatibility In Vitro.Molecules (Basel, Switzerland) · 2026Article
- CRISPR-Cas9 disruption of flavanone 3-hydroxylase produces a green phenotype and alters flavone metabolites in allotetraploid perilla.Frontiers in plant science · 2026Article
- Synergistic effect of combined cisplatin and rosmarinic acid on apoptosis and migration of head and neck cancer cell lines.Journal of dental sciences · 2026Article
- Culture System and Nutrient Restriction Shape Antioxidant Activity inPlants (Basel, Switzerland) · 2025Article
- Influence of Biotic and Abiotic Elicitors on Rosmarinic Acid Accumulation in Hairy Root Cultures ofPlants (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The ester of caffeic acid with α-hydroxydihydrocaffeic acid, named rosmarinic acid (α-o-caffeoyl-3,4-dihydroxyphenyllactic acid; RA) can occur as oligomeric molecules, or in free, esterified, and glycosidic forms. Although it is commonly found among the members of the plants from the Lamiaceae (mints) and Boraginaceae (borages) families, only certain plant species produce a comparatively high concentration of RA. This valuable bioactive compound exhibits anti-cancer, anti-angiogenic, antioxidant, anti-inflammatory, antiviral, and antimicrobial properties, among others. As it is difficult to obtain high quantities of RA from natural sources, and since chemical manufacturing is costly and challenging, various biotechnological methods have recently been investigated to boost RA production. Plant cell tissue culture has been used to promote RA production in various plant species, particularly medicinal ones, with elicitation being the most commonly used technique. This review explores the main steps involved in RA biosynthesis in plants, including the molecular mechanisms and physiological alterations underlying its function, along with the primary mechanisms of RA accumulation in response to elicitation. Recent progress in synthetic biology-based RA synthesis, as well as metabolic engineering techniques to enhance the industrial production of this valuable bioactive constituent, are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.