Evidence map›Paper›PMID 40497991›Full record

ArticleCells2025

Efficient Generation of Induced Pluripotent Stem Cell-Derived Definitive Endoderm Cells with Growth Factors and Small Molecules.

Faizal Z Asumda, Shadia Alzoubi, Kiyasha Padarath, Nina John, Kimya Jones, Ravindra Kolhe, Ashis Kumar Mondal, Tae Jin Lee, Wenbo Zhi, Robert C Huebert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Faizal Z AsumdaDepartment of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Shadia AlzoubiDepartment of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Kiyasha PadarathDepartment of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-5969-9392
Nina JohnMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Kimya JonesDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8283-2403
Ashis Kumar MondalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3826-9489
Tae Jin LeeCenter for Biotechnology and Genomics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Wenbo ZhiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-7720-7048
Robert C HuebertDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-9812-7573
Nathan P StaffDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Lindsey A KirkebyCenter for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN 55905, USA.

Funding

Molecular Mechanisms of Cholestatic FibrogenesisR01DK117861 · NIDDK · MAYO CLINIC ROCHESTER · PI Robert Christian Huebert · 2019 to 2026
$2.8M
NIDDK NIH HHS DK127861NIDDK NIH HHS R01 DK117861
6 · The paper itself

Abstract

Definitive endoderm (DE) differentiation leads to the development of the major internal organs including the liver, intestines, pancreas, gall bladder, prostate, bladder, thyroid, and lungs. The two primary methods utilized for

Indexed as

EndodermInduced Pluripotent Stem CellsIntercellular Signaling Peptides and ProteinsSmall Molecule LibrariesActivinsCell DifferentiationHumansPyridinesPyrimidinesActivinsChir 99021Intercellular Signaling Peptides and ProteinsPyridinesPyrimidinesSmall Molecule Librariesdefinitive endodermgrowth factorinduced pluripotent stem cell cellssmall molecule

Identifiers

PMID40497991
PMCPMC12153844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.