Evidence map›Paper›PMID 40497984›Full record

ArticleCells2025

Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET.

Janine Wesslowski, Sadia Safi, Michelle Rottmann, Melanie Rothley, Gary Davidson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Janine WesslowskiInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.ORCID 0000-0003-3674-1372
Sadia SafiInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.
Michelle RottmannInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.ORCID 0000-0003-2465-612X
Melanie RothleyInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.
Gary DavidsonInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany.ORCID 0000-0002-2264-5518

Funding

Deutsche Forschungsgemeinschaft 331351713 - SFB 1324 (project A06 to G.D.)
6 · The paper itself

Abstract

Upon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD

Indexed as

Frizzled ReceptorsWnt3A ProteinWnt-5a ProteinWnt ProteinsAnimalsHEK293 CellsHumansProtein BindingWnt Signaling PathwayFrizzled ReceptorsWnt3A ProteinWNT3A protein, humanWnt-5a ProteinWNT5A protein, humanWnt ProteinsGFP-WntHiBiTHiBiT-FZDligand–receptor bindingLRP6NanoBiT/BRETWnt-FZD bindingWnt signaling

Identifiers

PMID40497984
PMCPMC12153800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.