Evidence map›Paper›PMID 40497975›Full record

ArticleCells2025

Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model.

María Del Mar Figueroa-Gispert, Claudia M Ramos-Lugo, Carlimar Ocasio-Malavé, Rizaldy P Scott, Jared T Ahrendsen, Mercedes Gomez-Samblas, Antonio Osuna, Stephanie M Dorta-Estremera, Ana M Espino

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Del Mar Figueroa-GispertDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0002-7565-0193
Claudia M Ramos-LugoDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.
Carlimar Ocasio-MalavéDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0009-0009-7046-1076
Rizaldy P ScottMouse Histology & Phenotyping Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0288-8862
Jared T AhrendsenMouse Histology & Phenotyping Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-9309-6544
Mercedes Gomez-SamblasInstitute of Biotechnology, Department of Parasitology, University of Granada, 18071 Granada, Spain.ORCID 0000-0003-4801-528X
Antonio OsunaInstitute of Biotechnology, Department of Parasitology, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-3818-1471
Stephanie M Dorta-EstremeraDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.
Ana M EspinoDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0001-8456-2550

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
Targeting professional APCs using Fasciola hepatica FABP to suppresses inflammationSC1AI155439 · NIAID · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ESPINO, ANA M · 2020 to 2023
$1.5M
NCI NIH HHS P30 CA060553NIAID NIH HHS 1SC1AI155439-01NIAID NIH HHS SC1 AI155439NIGMS NIH HHS R25 GM061838
6 · The paper itself

Abstract

Ulcerative colitis (UC) is the most prevalent inflammatory bowel disease (IBD) in the USA. Current treatments present clinical limitations, underscoring the need for innovative therapeutics that promote an anti-inflammatory immune response. This study evaluates the anti-inflammatory potential of Fh15, a recombinant

Indexed as

Colitis, UlcerativeColonFatty Acid-Binding ProteinsHelminth ProteinsInflammationLeukocytesAnimalsDextran SulfateDisease Models, AnimalMacrophagesMaleMiceMice, Inbred C57BLPeroxidaseDextran SulfateFatty Acid-Binding ProteinsHelminth ProteinsPeroxidasechitinase-3 like-protein-1Fasciola hepaticafatty acid binding proteinIL-1βmacrophagesmyeloperoxidaseneutrophilsS100A9TNF-αulcerative colitis

Identifiers

PMID40497975
PMCPMC12153920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.