Evidence map›Paper›PMID 40497974›Full record

ArticleCells2025

Regulation of WDFY1 Expression by miRNAs, Transcription Factors, and IL-6 in Murine Mesangial Cells.

David E Adams, Siru Li, Yuxuan Zhen, Ahmet Kaynak, Xiaoyang Qi, Jane J Yu, Wen-Hai Shao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David E AdamsDivision of Rheumatology, Allergy & Immunology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Siru LiDivision of Pulmonary Disease, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Yuxuan ZhenDivision of Rheumatology, Allergy & Immunology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Ahmet KaynakDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-6551-1125
Xiaoyang QiDivision of Hematology & Oncology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0001-5363-1760
Jane J YuDivision of Pulmonary Disease, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Wen-Hai ShaoDivision of Rheumatology, Allergy & Immunology, Department of Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-4397-0539

Funding

Acidic Phospholipid-Selective Treatment for NeuroblastomaR01CA158372 · NCI · UNIVERSITY OF CINCINNATI · PI QI, XIAOYANG · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA158372
6 · The paper itself

Abstract

WD40 repeat and FYVE containing protein 1 (WDFY1) functions in membrane trafficking and protein complex scaffolding. WDFY1 has been studied in the immune system and in different oncogenic conditions. Therefore, comprehensive understanding of WDFY1 regulation mechanisms is much desired. In this study, we analyzed the promoter and 5'- and 3'-untranslated regions (UTRs) of

Indexed as

Interleukin-6Mesangial CellsMicroRNAsTranscription Factors3' Untranslated Regions5' Untranslated RegionsAnimalsGene Expression RegulationHeLa CellsHumansMicePromoter Regions, Genetic3' Untranslated Regions5' Untranslated RegionsInterleukin-6MicroRNAsTranscription FactorsIL-6luciferasemiRNAtranscription factorWDFY1

Identifiers

PMID40497974
PMCPMC12153811

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.