Evidence map›Paper›PMID 40497968›Full record

ArticleCells2025

Insulin-Degrading Enzyme Regulates mRNA Processing and May Interact with the CCR4-NOT Complex.

Barbara Bertocci, Ayse Yilmaz, Emmanuelle Waeckel-Énée, Chiara Guerrera, Kevin Roger, Lamine Touré, Peter M van Endert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbara BertocciUniversité Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015 Paris, France.
Ayse YilmazUniversité Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015 Paris, France.
Emmanuelle Waeckel-ÉnéeUniversité Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015 Paris, France.
Chiara GuerreraUniversité Paris Cité, INSERM, CNRS, Structure Fédérative de Recherche Necker, Proteomics Platform, F-75015 Paris, France.ORCID 0000-0002-4832-6793
Kevin RogerUniversité Paris Cité, INSERM, CNRS, Structure Fédérative de Recherche Necker, Proteomics Platform, F-75015 Paris, France.ORCID 0000-0003-1353-3415
Lamine TouréUniversité Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, Bioinformatics Hub, F-75015 Paris, France.ORCID 0009-0008-4566-6208
Peter M van EndertUniversité Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades, F-75015 Paris, France.ORCID 0000-0003-3782-0750

Funding

Agence Nationale de Recherche ANR-18-CE92-0008
6 · The paper itself

Abstract

Insulin-degrading enzyme is a zinc metalloprotease that degrades low-molecular-weight substrates, including insulin. Ubiquitous expression, high evolutionary conservation, upregulation of Ide in stress situations, and literature findings suggest a broader function of Ide in cell physiology and protein homeostasis that remains to be elucidated. We used proteomics and transcriptomics approaches to search for leads related to a broader role of Ide in protein homeostasis. We combined an analysis of the proteome and single-cell transcriptome of

Indexed as

InsulysinRNA, MessengerRNA Processing, Post-TranscriptionalTranscription FactorsAnimalsHumansIslets of LangerhansMiceProtein BindingCNOT1 protein, humanInsulysinRNA, MessengerTranscription Factorsbeta cellCCR4-NOTinsulinaseislet of Langerhansprotein homeostasisRNA processing

Identifiers

PMID40497968
PMCPMC12153694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.