Evidence map›Paper›PMID 40497965›Full record

ArticleCells2025

Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC.

David Krum, Saskia Rösch, Rolf Warta, Carolin Mogler, Miray-Su Yılmaz Topçuoğlu, Niels Grabe, Patrick J Schuler, Gerhard Dyckhoff, Christel Herold-Mende

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David KrumDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Saskia RöschDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Rolf WartaDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.ORCID 0000-0003-2821-4361
Carolin MoglerInstitute of Pathology, TUM School of Medicine, Technical University of Munich, Trogerstr. 18, 81675 Munich, Germany.ORCID 0000-0003-3400-7254
Miray-Su Yılmaz TopçuoğluDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Niels GrabeHamamatsu Tissue Imaging and Analysis Center, BioQuant, University of Heidelberg, INF 267, 69120 Heidelberg, Germany.
Patrick J SchulerDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.
Gerhard DyckhoffDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.ORCID 0000-0002-4316-4908
Christel Herold-MendeDepartment of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty of Heidelberg, University of Heidelberg, INF 400, 69120 Heidelberg, Germany.ORCID 0000-0002-1915-745X

Funding

DFG 504016957DFG 520051240
6 · The paper itself

Abstract

Patients with head and neck squamous cell carcinoma (HNSCC) suffer from severe morbidity and mortality. Immunotherapy represents a novel promising treatment option. Therefore, a better understanding of the immune niche is needed. This study focuses on the spatial distribution and prognostic value of different T cell subtypes in 84 HNSCC specimens as well as chemokine and cytokine levels associated with spatial T cell infiltration. Density of T helper (T

Indexed as

Biomarkers, TumorCyclin-Dependent Kinase Inhibitor p16Head and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckT-Lymphocyte SubsetsAdultAgedCytokinesFemaleHumansMaleMiddle AgedPrognosisT-Lymphocytes, RegulatoryTumor MicroenvironmentBiomarkers, TumorCyclin-Dependent Kinase Inhibitor p16CytokinesCCL4CXCL10cytokineHNSCCIL-9regulatory T cellsurvivalTILVEGF

Identifiers

PMID40497965
PMCPMC12153745

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.