Evidence map›Paper›PMID 40497959›Full record

ArticleCells2025

Mouse SPAG6L, a Key Cytoskeleton Modulator Essential for Male Germ Cell Development, Is Not Required for Sertoli Cell Function.

Tao Li, Wei Li, Cheng Zheng, Jannette M Dufour, William H Walker, Shuiqiao Yuan, Zhibing Zhang

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tao LiInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0003-0362-8824
Wei LiDepartment of Physiology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0002-0940-8155
Cheng ZhengDepartment of Physiology, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-4593-6091
Jannette M DufourDepartment of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.ORCID 0000-0001-5623-519X
William H WalkerDepartment of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Shuiqiao YuanInstitute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.ORCID 0000-0003-1460-7682
Zhibing ZhangDepartment of Physiology, Wayne State University, Detroit, MI 48201, USA.

Funding

Intraflagellar transport (IFT) and sperm formationR01HD105944 · NICHD · WAYNE STATE UNIVERSITY · PI Zhibing Zhang · 2022 to 2026
$2.4M
The mechanisms of MEIG1 complex in mammalian spermiogenesis and fertilizationR01HD114311 · NICHD · WAYNE STATE UNIVERSITY · PI Saher Sue Hammoud, Christopher V Kelly · 2024 to 2026
$1.9M
Targeting the MEIG1/PACRG interaction for male contraception.R21HD107579 · NICHD · WAYNE STATE UNIVERSITY · PI ZHANG, ZHIBING · 2022 to 2023
$424k
NICHD NIH HHS R01 HD105944NICHD NIH HHS R01 HD114311NICHD NIH HHS R21 HD107579NIH HHS This research was supported by Wayne State University start-up funds and by the National Institutes of Health under award numbers HD105944, HD107579 and HD114311 (Z.Z.). J.M.D. was supported in part by the Robert A. Welch Foundation (B1-0028, J.M.D.)
6 · The paper itself

Abstract

Mouse sperm-associated antigen 6-like (SPAG6L) evolved from SPAG6, the mammalian ortholog of Chlamydomonas PF16, which is localized in the central apparatus of the motile cilia and is essential for ciliary motility. Even though the amino acid sequences of the two SPAG6 proteins are highly similar, the two proteins have different biological expression patterns in vivo. No major phenotypes were discovered in the global

Indexed as

CytoskeletonGerm CellsMicrotubule ProteinsSertoli CellsSpermatozoaAnimalsBlood-Testis BarrierCiliaMaleMiceMice, KnockoutMicrotubulesSpermatogenesisTestisMicrotubule ProteinsSPAG6 protein, mouseaxonemecentral apparatusciliaSertoli cellsSpag6lspermatogenesis

Identifiers

PMID40497959
PMCPMC12153848

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.