Evidence map›Paper›PMID 40497864›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Functionalized Silver Nanoparticles as Multifunctional Agents Against Gut Microbiota Imbalance and Inflammation.

Mihaela Stoyanova, Vera Gledacheva, Miglena Milusheva, Mina Todorova, Nikoleta Kircheva, Silvia Angelova, Iliyana Stefanova, Mina Pencheva, Yulian Tumbarski, Bela Vasileva and 6 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mihaela StoyanovaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0009-0008-8086-9094
Vera GledachevaDepartment of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-4155-956X
Miglena MilushevaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0001-6224-7584
Mina TodorovaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-0850-0902
Nikoleta KirchevaInstitute of Optical Materials and Technologies "Acad. J. Malinowski", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-6645-8319
Silvia AngelovaInstitute of Optical Materials and Technologies "Acad. J. Malinowski", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-4717-8028
Iliyana StefanovaDepartment of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.ORCID 0000-0001-6553-6365
Mina PenchevaDepartment of Medical Physics and Biophysics, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.ORCID 0000-0002-0411-2291
Yulian TumbarskiDepartment of Microbiology and Biotechnology, Technological Faculty, University of Food Technologies, 4002 Plovdiv, Bulgaria.ORCID 0000-0003-1674-5333
Bela VasilevaLaboratory of Molecular Genetics, Epigenetics and Longevity, Institute of Molecular Biology "R. Tsanev", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-8718-6412
Kamelia Hristova-PanushevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-8348-8336
Zlatina GospodinovaInstitute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl.21, 1113 Sofia, Bulgaria.ORCID 0000-0001-7976-7631
Natalia KrastevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-7423-7412
George MiloshevLaboratory of Molecular Genetics, Epigenetics and Longevity, Institute of Molecular Biology "R. Tsanev", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-2979-8899
Milena GeorgievaLaboratory of Molecular Genetics, Epigenetics and Longevity, Institute of Molecular Biology "R. Tsanev", Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-2371-7544
Stoyanka NikolovaDepartment of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-4649-7935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human pathogenic fungi are the source of various illnesses, including invasive, cutaneous, and mucosal infections. One promising solution is using nanoparticles (NPs) as an antifungal agent. The current study aims to assess the antimicrobial and antifungal effects of drug-loaded silver nanoparticles (AgNPs) with previously reported mebeverine analogue (MA) as a potential drug candidate targeting gut microbiota and inflammation in the gastrointestinal tract. Density Functional Theory (DFT) calculations were conducted to identify possible mechanisms by which AgNPs could prevent microorganisms from growing. In vitro and ex vivo anti-inflammatory, in vitro antimicrobial, ex vivo spasmolytic activities, and in vitro hepatic cell morphology and proliferation of drug-loaded AgNPs were assessed. The drug-loaded AgNPs were considered to have promising antifungal activity against all tested fungal strains,

Indexed as

antifungalanti-inflammatory activityantimicrobialDFTsilver nanoparticlesspasmolytic

Identifiers

PMID40497864
PMCPMC12157222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.