Evidence map›Paper›PMID 40497723›Full record

ArticleJournal of virology2025

Replication-deficient whole-virus vaccines against cytomegalovirus induce protective immunity in a guinea pig congenital infection model.

Mark R Schleiss, Claudia Fernández-Alarcón, Craig J Bierle, Adam P Geballe, Alexey Badillo-Guzman, Christine E Tanna, Kanokpan Tsriwong, Mark Blackstad, Jian Ben Wang, Michael A McVoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mark R SchleissDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-2108-9433
Claudia Fernández-AlarcónDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Craig J BierleDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-7890-7409
Adam P GeballeFred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0002-9279-6653
Alexey Badillo-GuzmanDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Christine E TannaDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Kanokpan TsriwongDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Mark BlackstadDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Jian Ben WangDepartment of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Michael A McVoyDepartment of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID 0000-0001-7949-7870

Funding

Optimizing Immunity and Maternal Host Defense Against Congenital Cytomegalovirus InfectionR01HD098866 · NICHD · UNIVERSITY OF MINNESOTA · PI Craig John Bierle, Michael A McVoy · 2019 to 2026
$3.9M
Summer Research Training at the University of Minnesota Medical SchoolR25HL088728 · NHLBI · UNIVERSITY OF MINNESOTA · PI COLIN R CAMPBELL, Dang Hai Nguyen · 2007 to 2026
$2.9M
Medical Student Summer Research Program in Infection and ImmunityT35AI118620 · NIAID · UNIVERSITY OF MINNESOTA · PI MUELLER, DANIEL L · 2015 to 2025
$351k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD098866Infectious Diseases Society of America G.E.R.M. AwardNHLBI NIH HHS NHLBI R25HL088728NHLBI NIH HHS R25 HL088728NIAID NIH HHS T35 AI118620NICHD NIH HHS R01 HD098866NIH HHS T35AI118620
6 · The paper itself

Abstract

Vaccines are needed to prevent congenital human cytomegalovirus (HCMV) infections. This study used the guinea pig cytomegalovirus (GPCMV) model to examine replication-deficient whole-virus vaccines for protection against maternal viremia and congenital CMV infection. Two recombinant GPCMVs, GP51-DD and GP52-DD, were engineered with destabilization domains fused to the essential viral late proteins GP51 and GP52. These viruses, predicted to replicate in the presence of the synthetic ligand Shield-1 but not in its absence, were evaluated for Shield-1 dependence

Indexed as

CytomegalovirusCytomegalovirus InfectionsCytomegalovirus VaccinesRoseolovirusAnimalsAntibodies, ViralDisease Models, AnimalFemaleGuinea PigsHumansPregnancyViremiaVirus ReplicationAntibodies, ViralCytomegalovirus Vaccinescongenital cytomegaloviruscytomegaloviruscytomegalovirus vaccineDISC vaccineGuinea pig

Identifiers

PMID40497723
PMCPMC12282073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.