Evidence map›Paper›PMID 40497717›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2025

Unlocking the potential of trifluoromethyl pyrrole derivatives in chronic wounds management: rapid synthesis, structural insights, and potent antimicrobial activity.

Rafaela Vrabie, Mariana Pinteala, Cristina M Al-Matarneh, Ioana C Marinas, Alina Nicolescu, Sergiu Shova, Mihaela Silion, Mădălina-Diana Gaboreanu, Mariana C Chifiriuc

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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rafaela VrabieCenter of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Mariana PintealaCenter of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Cristina M Al-MatarnehCenter of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Ioana C MarinasResearch Institute of the University of Bucharest-ICUB, Bucharest, Romania.
Alina NicolescuNMR Laboratory, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Sergiu ShovaDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Mihaela SilionPhysics of Polymers and Polymeric Materials Department, "Petru Poni" Institute of Macromolecular Chemistry, Iasi, Romania.
Mădălina-Diana GaboreanuResearch Institute of the University of Bucharest-ICUB, Bucharest, Romania.
Mariana C ChifiriucResearch Institute of the University of Bucharest-ICUB, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a one-pot, three-component approach, we synthesised 25 dihydropyrrol-2-one and two 5-oxo-2,5-dihydrofuran compounds, each featuring two trifluoromethyl groups. This method emphasises timeliness and cost-effectiveness, crucial in drug development. Structural verification was conducted using NMR, FT-IR, MALDI-MS, single-crystal, and powder XRD. The antibacterial and antifungal activities of these compounds were evaluated on yeasts (

Indexed as

Anti-Bacterial AgentsAntifungal AgentsPyrrolesCandidaDose-Response Relationship, DrugHumansMicrobial Sensitivity TestsMolecular StructureStaphylococcus aureusStructure-Activity RelationshipWound HealingAnti-Bacterial AgentsAntifungal AgentsPyrrolesantimicrobial activitychronic woundsDihydro-pyrrol-2-oneDoebner-type synthesistrifluoromethyl

Identifiers

PMID40497717
PMCPMC12160334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.