Evidence map›Paper›PMID 40497674›Full record

Observational studyActa paediatrica (Oslo, Norway : 1992)2025

Spontaneous Intestinal Perforation in Extremely Premature Infants Exposed to Early Low-Dose Hydrocortisone.

Gilles Cambonie, Anais Jouffrey, Benoit Tessier, Clémentine Combes, Angelo Polito, Arthur Gavotto

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gilles CambonieDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0002-1360-7915
Anais JouffreyDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, Montpellier, France.
Benoit TessierDepartment of Pediatric Surgery, Lapeyronie Hospital, Montpellier University Hospital Centre, University of Montpellier, Montpellier, France.
Clémentine CombesDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, Montpellier, France.
Angelo PolitoPediatric Intensive Care Unit, Department of Woman, Child, and Adolescent Medicine, Geneva University Hospital, Geneva, Switzerland.
Arthur GavottoDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, Montpellier, France.ORCID https://orcid.org/0000-0001-6485-7634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess the occurrence of spontaneous intestinal perforation (SIP) in < 28 weeks' gestational age (GA) infants exposed to early low-dose hydrocortisone (ELH) to reduce the risk of bronchopulmonary dysplasia (BPD). Additionally, the risk of SIP was assessed in infants exposed to early concomitant treatment with ibuprofen for persistent ductus arteriosus (PDA).

methodsObservational study in a tertiary neonatal centre preceding and following hydrocortisone implementation. Exposed and non-exposed infants were compared after matching on delivery mode, multiple pregnancy, GA, birthweight, sex and using multivariate logistic regression analysis.

resultsAmong 653 infants, 259 (40%) had been exposed to hydrocortisone, and 210 from each group could be paired. Exposed infants had a higher rate of SIP (8.1% vs. 2.9%, OR [95% CI] 2.99 [1.15-7.74]). Early ibuprofen was provided to 110 exposed (52%) and 105 nonexposed (50%). The rate of SIP was higher in exposed infants cotreated with ibuprofen (11.8% vs. 3.8%, OR 3.38 [1.07-10.73]). Logistic regression analysis in the whole cohort confirmed the risk of SIP in infants exposed to concomitant treatment (OR [95% CI] 2.93 [1.24-6.93]).

conclusionEarly concomitant treatment with ELH and ibuprofen is associated with an increased risk of SIP in infants born < 28 weeks.

Indexed as

Anti-Inflammatory AgentsHydrocortisoneInfant, Premature, DiseasesIntestinal PerforationBronchopulmonary DysplasiaDuctus Arteriosus, PatentFemaleHumansIbuprofenInfant, Extremely PrematureInfant, NewbornMaleAnti-Inflammatory AgentsHydrocortisoneIbuprofenbronchopulmonary dysplasiaextremely premature infanthydrocortisoneibuprofenintestinal perforation

Identifiers

PMID40497674
PMCPMC12520270

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.