ArticleJournal of the American Heart Association2025
Decades of Shifting Trends: Arrhythmia-Related Mortalities in the United States (1968-2021) With 2040 Projections.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via GScientific reports · 2026Article
- Arrhythmia-Related Cardiovascular Disease Mortality Among Asian American, Native Hawaiian, and Pacific Islander Groups.Circulation. Arrhythmia and electrophysiology · 2026Article
- The impact of the PI3K/AKT pathway on arrhythmia: mechanisms of action and therapeutic potential.Journal of molecular histology · 2026Review
- Cardiac resident macrophages: the emerging role in arrhythmogenesis.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArrhythmias are a significant public health concern, and understanding their evolving patterns is vital for informed health care planning. This study explores trends and disparities in arrhythmia-related mortality rates in the United States from 1968 to 2021, projecting up to 2040.
methodsWe examined national death records for cardiovascular deaths linked to arrhythmia among individuals aged 15 to 84 years, using the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research. Age-adjusted mortality rates (AAMRs) were calculated, and trends were evaluated. Subgroup analyses were conducted on the basis of arrhythmia subtypes, age, sex, race, and geographic regions. AAMRs for 2040 were projected using Autoregressive Integrated Moving Average forecasting.
resultsOverall AAMRs increased from 1968 to 2021, peaking in 1988 before declining, then slightly increasing after 2006. Atrial fibrillation- or flutter-related fatalities surpassed cardiac arrest-related deaths after 2006. Sex disparities decreased, with men maintaining higher crude mortality rates, but the gap narrowed. Younger populations witnessed an upward trend in AAMRs after 2006. Racial disparities persisted, with Black populations experiencing higher AAMRs than White populations.
conclusionsThis study provides insights into evolving arrhythmia-related death. While overall AAMRs may stabilize by 2040, the projected rise in atrial fibrillation-related deaths, particularly among younger populations, necessitates further investigation. Additional research is needed to determine whether this trend reflects a true epidemiologic shift or improvements in detection and reporting. Furthermore, identifying underlying risk factors and developing targeted interventions will be crucial in mitigating AF-related death in younger adults. Persistent racial disparities underscore the importance of equitable health care strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.