SynthesisJournal of the American Heart Association2025
Selection by Noncontrast Computed Tomography With or Without Computed Tomography Angiography Versus Computed Tomography Perfusion for Endovascular Therapy in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Review
- CTA imaging characteristics and endovascular therapy effect in patients with large ischemic stroke: a prospective cohort study.Neurological research and practice · 2026Article
- Evaluating the Safety and Efficacy of Intravenous Thrombolysis in Acute Ischemic Stroke Patients Without Perfusion Deficit: A Retrospective Analysis.Brain sciences · 2025Article
- Earlier endovascular therapy within 24 h of ischemic stroke is associated with attenuated systemic inflammation and better neurological recovery.Frontiers in neurologyArticle
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of imaging selection on endovascular therapy for acute ischemic stroke remains debated. We compared the efficacy and safety of imaging modalities using computed tomography perfusion with using noncontrast computed tomography (NCCT)±computed tomography angiography.
methodsStudies from PubMed, Embase, and Cochrane Library up to March 1, 2024, were analyzed. Sixteen studies (12 199 patients) assessed functional independence (modified Rankin Scale score of 0-2 at 90 days) using odds ratios (ORs). This study was registered with the International Prospective Register of Systematic Reviews (CRD42024519554).
resultsNo significant differences were observed in functional independence (OR, 1.09 [95% CI, 0.98-1.21]), modified Rankin Scale score of 0 to 1 (OR, 1.07 [95% CI, 0.88-1.29]), 0 to 3 (OR, 1.04 [95% CI, 0.92-1.18]), thrombolysis in cerebral infarction 2b to 3 (OR, 1.08 [95% CI, 0.95-1.22]), symptomatic intracranial hemorrhage (OR, 0.87 [95% CI, 0.74-1.04]), and any intracranial hemorrhage (OR, 0.95 [95% CI, 0.80-1.12]) between the computed tomography perfusion and NCCT group. There was a significantly lower odds of death during follow-up in the computed tomography perfusion group compared with the NCCT group (OR, 0.78 [95% CI, 0.70-0.88]). Comparison of modified Rankin Scale score of 0 to 2 significantly favored NCCT selection for patients with large cores (
conclusionsThese findings indicate that patients undergoing endovascular therapy selected with computed tomography perfusion had a similar functional prognosis compared with those selected with NCCT but had lower odds of death during follow-up. NCCT-defined large-core patients had better functional outcomes.
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