Evidence map›Paper›PMID 40497496›Full record

ArticleEpigenetics2025

The myoblast methylome: multiple types of associations with chromatin and transcription.

Sagnik Sen, Michelle Lacey, Carl Baribault, V K Chaithanya Ponnaluri, Pierre Olivier Esteve, Kenneth C Ehrlich, Mia Meletta, Sriharsa Pradhan, Melanie Ehrlich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sagnik SenMolecular Genetics and Genomics, New England Biolabs, Ipswich, MA, USA.ORCID 0000-0002-3362-1677
Michelle LaceyDepartment of Mathematics, Tulane University, New Orleans, LA, USA.ORCID 0000-0002-0926-4593
Carl BaribaultInformation Technology, Tulane University, New Orleans, LA, USA.ORCID 0009-0004-0376-0221
V K Chaithanya PonnaluriMolecular Genetics and Genomics, New England Biolabs, Ipswich, MA, USA.ORCID 0000-0002-1033-5379
Pierre Olivier EsteveMolecular Genetics and Genomics, New England Biolabs, Ipswich, MA, USA.ORCID 0009-0008-6741-9187
Kenneth C EhrlichCenter for Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA, USA.ORCID 0009-0007-7001-2305
Mia MelettaDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA.ORCID 0009-0004-9537-0203
Sriharsa PradhanMolecular Genetics and Genomics, New England Biolabs, Ipswich, MA, USA.ORCID 0000-0003-1710-0588
Melanie EhrlichCenter for Bioinformatics and Genomics, Tulane University Health Sciences Center, New Orleans, LA, USA.ORCID 0000-0002-8187-4476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic changes are implicated in development, repair, and physiology of postnatal skeletal muscle (SkM). We generated methylomes for human myoblasts (SkM progenitor cells) and determined myoblast differentially methylated regions (DMRs) for comparison to the epigenomics and transcriptomics of diverse cell types. Analyses were from global genomic and single-gene perspectives and included reporter gene assays. One atypical finding was the association of promoter-adjacent hypermethylation in myoblasts with transcription turn-on, but at downmodulated levels, for certain genes (

Indexed as

ChromatinDNA MethylationEpigenomeMyoblastsTranscription, GeneticBasic Helix-Loop-Helix ProteinsCCCTC-Binding FactorEpigenesis, GeneticHistonesHumansMyoD ProteinPromoter Regions, GeneticBasic Helix-Loop-Helix ProteinsCCCTC-Binding FactorChromatinCTCF protein, humanHistonesMyoD ProteinCTCFDNA methylationenhancersenzymatic methyl-seq (EM-seq)MyoblastsMYODskeletal musclewhole-genome bisulfite sequencing (WGBS)

Identifiers

PMID40497496
PMCPMC12160609

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.