ReviewAllergy2025
Regulatory T cells and their role in allergic disease.
Review in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Review
- New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report.Clinical and translational allergy · 2026Review
- Preventive effect of heat-killed Lactiplantibacillus plantarum FM8 in an ovalbumin-induced food allergy murine model.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026Article
- Regulation of mCell biology and toxicology · 2026Review
- Development and evaluation of Sargassum polysaccharides-algal oil nanoemulsion for intranasal treatment of allergic rhinitis.Bioresources and bioprocessing · 2026Article
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- The Cardiovascular Disease Continuum: From Cardiovascular Risk Factors to Heart Failure.Life (Basel, Switzerland) · 2026Article
- Immune checkpoint-engineered virus-like particles induce antigen-specific immune tolerance and protect against food allergy.NPJ vaccines · 2026Article
- Saccharomyces cerevisiae UFMG A-905 acts in an animal model of asthma by modulating Th17/Treg responses and increasing fatty acid production.BMC microbiology · 2026Article
- T-cell mechanisms in atopic dermatitis.Allergologie select · 2026Review
- Breast milk miRNAs and their potential role in the development of atopy in infants.Frontiers in molecular biosciences · 2026Review
- IgE, anti-IgE therapy, and regulatory T cells: new paradigms in allergic inflammation.Frontiers in allergy · 2026Review
- Nanobiotic-Enhanced Probiotics for Targeted Gut Delivery: Mechanisms, Therapeutic Applications, and Translational Challenges.International journal of nanomedicine · 2026Review
- Context-dependent roles of the gut microbiome in food allergy tolerance versus sensitization.Gut microbes · 2025Review
- SIRT3-SUMO regulated Treg cell differentiation and asthma development by mediating N-glycosylation through the FAO pathway.Cell biology and toxicology · 2025Article
- Infection with Helicobacter pylori and the age at onset of coeliac disease in the "HUNT4" survey.BMC research notes · 2025Article
- Early-life viral infections and asthma: new cells and ideas.Current opinion in pediatrics · 2025Review
- The Mechanisms of Immunoglobulin E Sensitizations in Atopic Dermatitis.Immunology and allergy clinics of North America · 2025Review
- The Junction of Allergic Inflammation and Atherosclerosis: Pathways and Clinical Implications-A Review.Life (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The incidence of allergic diseases has been rising over the past decades, and this troubling trend coincides with environmental changes such as shifts in diet and increased antibiotic use, both of which can impact our immune system. Allergic reactions occur when the immune system overreacts to normally harmless substances, and it is known that regulatory T cells (Tregs) play a major role in immune system suppression and the generation of tolerance. However, new research suggests that Tregs can malfunction in environments that promote allergies. This review delves into Treg function, and how environmental factors can influence their ability to maintain immune homeostasis. Specifically, we explore the origins of Treg cells, as well as the mechanisms used for suppression of inflammation and tissue healing, with a concentration on food allergies, atopic dermatitis and asthma. Understanding Treg function in the context of a changing environment is crucial for developing new strategies to prevent and treat allergies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.