Evidence map›Paper›PMID 40497449›Full record

ArticleeLife2025

Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI.

Joonas A Autio, Ikko Kimura, Takayuki Ose, Yuki Matsumoto, Masahiro Ohno, Yuta Urushibata, Takuro Ikeda, Matthew F Glasser, David C van Essen, Takuya Hayashi

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Joonas A AutioLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID https://orcid.org/0000-0002-2232-9259
Ikko KimuraLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Takayuki OseLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Yuki MatsumotoLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Masahiro OhnoLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Yuta UrushibataSiemens Healthcare K.K., Tokyo, Japan.
Takuro IkedaLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.
Matthew F GlasserDepartment of Radiology, Washington University in St. Louis, St. Louis, United States.
David C van EssenDepartment of Neuroscience, Washington University in St. Louis, St. Louis, United States.
Takuya HayashiLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan.ORCID https://orcid.org/0000-0001-7639-0197

Funding

RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7M
Japan Agency for Medical Research and Development JP18dm037006Japan Agency for Medical Research and Development JP23wm0625001Japan Society for the Promotion of Science JP20K15945NIH HHS R01MH60974NIMH NIH HHS R01 MH060974
6 · The paper itself

Abstract

Mapping the vascular organization of the brain is of great importance across various domains of basic neuroimaging research, diagnostic radiology, and neurology. However, the intricate task of precisely mapping vasculature across brain regions and cortical layers presents formidable challenges, resulting in a limited understanding of neurometabolic factors influencing the brain's microvasculature. Addressing this gap, our study investigates whole-brain vascular volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo imaging in macaque monkeys. We validate the results with published data for vascular densities and compare them with cytoarchitecture, neuron and synaptic densities. The ferumoxytol-induced change in transverse relaxation rate (ΔR

Indexed as

BrainBrain MappingFerrosoferric OxideMagnetic Resonance ImagingAnimalsMacaca mulattaMaleFerrosoferric Oxidecortical layerferumoxytolneuroscienceneurovascularprimaterhesus macaquevasculature

Identifiers

PMID40497449
PMCPMC12158431

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.