Evidence map›Paper›PMID 40497242›Full record

ArticleTherapeutic advances in gastroenterology2025

Risk factors for recurrence after endoscopic papillectomy in ampullary adenomas: a retrospective case-control study.

Kun Liu, Yuhang Zhuang, Ningjing Gao, Muhan Ni, Xiang Zhang, Peng Yan, Quan Zhou, Zhao Shi, Pin Wang, Dehua Tang and 3 more

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Article in Therapeutic advances in gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kun LiuDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Yuhang ZhuangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Ningjing GaoDepartment of Gastroenterology, Jiangsu Provincial Medical Innovation Center for Digestive Disease, Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Muhan NiDepartment of Gastroenterology, Jiangsu Provincial Medical Innovation Center for Digestive Disease, Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Xiang ZhangDepartment of Gastroenterology, Jiangsu Provincial Medical Innovation Center for Digestive Disease, Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Peng YanDepartment of Gastroenterology, Nanjing International Hospital, Affiliated Nanjing International Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Quan ZhouDepartment of Gastroenterology, Jiangsu Provincial Medical Innovation Center for Digestive Disease, Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
Zhao ShiDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.
Pin WangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China.ORCID https://orcid.org/0000-0001-8939-5413
Dehua TangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.
Ying LvDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.
Lei WangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.ORCID https://orcid.org/0000-0003-0178-5930
Shanshan ShenDepartment of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing Medical University, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.ORCID https://orcid.org/0009-0000-7889-5674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endoscopic papillectomy (EP) has emerged as a preferred treatment modality for ampullary adenomas, offering a less-invasive alternative to surgical resection. However, concerns persist regarding the potential for incomplete resection and subsequent recurrence. Objectives: This study aims to evaluate the efficacy of EP in treating ampullary adenomas and to identify risk factors associated with recurrence. Design: This study was a single-center, retrospective case-control study. Methods: We retrospectively analyzed patients who underwent EP at Nanjing Drum Tower Hospital between January 2010 and December 2022. Recurrence rates were assessed, and potential risk factors for recurrence were analyzed using univariate and multivariate Cox proportional hazards models. Hazard ratios (HR) with corresponding 95% confidence intervals (CI) were calculated. Results: Among the 137 patients who achieved complete resection, 21 (15.3%) experienced recurrence. The median follow-up period was 17.7 months (interquartile range (IQR) 11.7-37.5), and the median time-to-recurrence was 16.2 months (IQR 9.9-33.9). Of the 21 recurrence cases, 11 (52.3%) were managed successfully with repeat endoscopic intervention, while 6 (28.6%) required pancreatoduodenectomy. Significant risk factors for recurrence included familial adenomatous polyposis (FAP; HR = 9.3; 95% CI: 2.8-30.4; Conclusion: EP is an effective treatment for ampullary adenomas; however, recurrence remains a significant concern, particularly among patients with FAP, PB subtype, and HGD.

Indexed as

ampullary adenomaendoscopic papillectomyrecurrence

Identifiers

PMID40497242
PMCPMC12149630

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.