Evidence map›Paper›PMID 40497189›Full record

ArticleCureus2025

Evaluation of Trypsin-Like Enzyme Activity Using a Novel Device for Monitoring Porphyromonas gingivalis in Periodontal Pockets: A Pilot Study.

Risako Mikami, Yasuo Takeuchi, Kazuyuki Ishihara, Yosuke Tsuchiya, Takahiko Nagai, Ryota Kobayashi, Takahiko Shiba, Takanori Iwata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Risako MikamiDepartment of Advanced Biomaterials, Institute of Science Tokyo, Tokyo, JPN.
Yasuo TakeuchiDepartment of Lifetime Oral Health Care Sciences, Institute of Science Tokyo, Tokyo, JPN.
Kazuyuki IshiharaDepartment of Microbiology, Tokyo Dental College, Tokyo, JPN.
Yosuke TsuchiyaDepartment of Periodontology, Institute of Science Tokyo, Tokyo, JPN.
Takahiko NagaiDepartment of Periodontology, Institute of Science Tokyo, Tokyo, JPN.
Ryota KobayashiDepartment of Periodontology, Institute of Science Tokyo, Tokyo, JPN.
Takahiko ShibaDepartment of Periodontology, Institute of Science Tokyo, Tokyo, JPN.
Takanori IwataDepartment of Periodontology, Institute of Science Tokyo, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background/purposeThis study evaluates the potential of a novel trypsin-like protease (TLP) measurement device for site-specific periodontal risk assessment, using TLP as a marker for bacterial risk, particularly for MATERIALS AND

methodsThirty participants were categorized into three groups: Healthy (n = 10), Perio (untreated periodontitis, n = 9), and Perio-SPC (supportive periodontal care, n = 11). Subgingival plaque samples were collected from the deepest periodontal pocket of the maxillary anterior teeth or single-rooted premolars. TLP activity was measured using the novel device, while

resultsThe TLP scores and

conclusionThe novel TLP measurement system showed potential as a site-specific tool for periodontal risk assessment and monitoring.

Indexed as

periodontal risk assessmentperiodontitisporphyromonas gingivalissite-specific diagnosistrypsin-like protease

Identifiers

PMID40497189
PMCPMC12149668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.