ArticleJournal of oral biology and craniofacial research
Role of salivary Insulin-like Growth Factor-1 (IGF-1) in the regulation of biomechanical process following mandibular advancement with a twin block appliance-a prospective observational study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An increased expression of Insulin-like growth factor-1 (IGF-1) in the condyle following mandibular advancement has been observed in animal studies. However, the exact role of IGF-1 in the regulation of biomechanical process of Twin block in humans is still unclear. Hence, the aim of the present study was to investigate the role of salivary IGF-1 following mandibular advancement with Twin block appliance in subjects having skeletal Class II malocclusion. Materials and methods: This prospective observational study enrolled 49 subjects with skeletal Class II malocclusion who were administered Twin block. Salivary samples were collected at: pre-treatment (T0), one week (T1), 6-10 weeks (T2), 8-10 months (T3) and post-treatment (T4). Subjects who were non-compliant were taken as the non-compliant group (NCG; n = 10), (Twin block group, TBG; n = 39). Lateral cephalograms were obtained at T0, T3 and T4 for TBG and at T0, T4 for NCG to evaluate the various skeletal and dentoalveolar effects. Friedman test, Wilcoxon signed test and Mann-Whitney Results: In TBG, salivary IGF-1 levels significantly increased at one week (p = 0.000), followed by a plateau, while NCG showed no significant changes. Cephalometric analysis revealed significant improvements in mandibular length and other parameters in TBG compared to NCG. Conclusions: The study demonstrates a significant increase in salivary IGF-1 levels following mandibular advancement, suggesting its regulatory role in biomechanical process of the Twin block appliance. Clinical relevance: The findings of this study hold significant future potential in the field of dentofacial orthopaedics. The development of a panel of salivary biomarkers could offer a more comprehensive understanding of the biological processes involved in mandibular advancement and growth, leading to more precise and customized treatment plans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.