Evidence map›Paper›PMID 40497136›Full record

ArticleFrontiers in neuroscience2025

Impacts of chronic intermittent ethanol vapor and predator odor on ethanol intake and striatal D

Cristiane Aparecida Favoretto, Allyson Nguyen, Gabriela R Chacon, Amanda J Roberts, Tali Nadav, Saumya Ranjan, Luisa Becker Bertotto, Fábio Cardoso Cruz, Eric P Zorrilla

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristiane Aparecida FavorettoDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Allyson NguyenDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Gabriela R ChaconDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Amanda J RobertsAnimal Models Core, The Scripps Research Institute, La Jolla, CA, United States.
Tali NadavAnimal Models Core, The Scripps Research Institute, La Jolla, CA, United States.
Saumya RanjanDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Luisa Becker BertottoDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Fábio Cardoso CruzDepartment of Pharmacology, Universidade Federal de São Paulo, São Paulo, Brazil.
Eric P ZorrillaDepartment of Translational Medicine, The Scripps Research Institute, La Jolla, CA, United States.

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Dorsal striatal phosphodiesterase 10A and compulsive ethanol useR01AA028879 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ZORRILLA, ERIC P · 2021 to 2025
$2.1M
PPARdelta receptors and alcohol use phenotypesR21AA029498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ZORRILLA, ERIC P · 2023 to 2024
$479k
NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA028879NIAAA NIH HHS R21 AA029498NIAAA NIH HHS T32 AA007456
6 · The paper itself

Abstract

Introduction: Stress is a risk factor for ethanol use disorders, which has been modeled by chronic intermittent ethanol (CIE) vapor exposure. Repeated stress alters CB Methods: Male C57BL/6J mice underwent three cycles of 4 days CIE or air exposure, alternated with 5 days ethanol access. During the last two cycles, mice were exposed to predator odor or control bedding before each drinking session. Following the last stressor, brains were processed for RNAscope to label Results: As hypothesized, predator odor accelerated the CIE-induced increase in ethanol intake. Contrary to our expectations, CIE did not alter corticosterone levels after the final stressor. Compared to control bedding, predator odor reduced the percentage of Discussion: Thus, CIE and stress elicited opposite neuroactivational effects on CB

Indexed as

alcoholCB1 cannabinoid receptorscorticosteroneD1-medium spiny neuronsFosstress

Identifiers

PMID40497136
PMCPMC12149174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.