Evidence map›Paper›PMID 40497086›Full record

ArticleWorld journal of gastroenterology2025

Obesity paradox role in the immunosuppressive treatment of hepatocellular carcinoma.

Leandro Sierra, Mohamad-Noor Abu-Hammour, Arjun Chatterjee, C Roberto Simons-Linares

Abstract readLetter
In one paragraph

Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leandro SierraDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Mohamad-Noor Abu-HammourDepartment of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
Arjun ChatterjeeDepartment of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
C Roberto Simons-LinaresDepartment of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. simonsc@ccf.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The "obesity paradox" in hepatocellular carcinoma (HCC) suggests patients with obesity may experience better treatment outcomes compared to patients without obesity. Wang

Indexed as

Carcinoma, HepatocellularImmunosuppressive AgentsLiver NeoplasmsObesityHepatitis BHumansImmune Checkpoint InhibitorsImmunotherapyObesity ParadoxPhenylurea CompoundsProgression-Free SurvivalQuinolinesSarcopeniaTreatment OutcomeWeight LossImmune Checkpoint InhibitorsImmunosuppressive AgentslenvatinibPhenylurea CompoundsQuinolinesAnti-programmed death-1 therapyAnti-vascular endothelial growth factor therapyHepatocellular carcinomaImmunotherapyLeptinObesity paradox

Identifiers

PMID40497086
PMCPMC12146916

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.