ArticleThe journal of allergy and clinical immunology. Global2025
Utility of serum cytokine testing to differentiate complicated common variable immunodeficiency in resource limited settings.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Elevated IL-10 is Linked With the Expansion of T-betJournal of clinical immunology · 2026Article
- From CVID to PIRD: Genetic Testing Leading to Signal Transducer and Activator of Transcription 3 Gain-of-Function Diagnosis and Directed Therapy.The journal of allergy and clinical immunology. In practice · 2026Article
- Quality and Safety Intervention: Improving Care of Patients Undergoing B Cell-Targeted Therapies.The journal of allergy and clinical immunology. In practice · 2026Article
- Sociodemographic drivers of care disparity among patients with inborn errors of immunity.Current opinion in pediatrics · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Background: Common variable immunodeficiency (CVID) is the most common, symptomatic inborn error of immunity (IEI) worldwide. CVID diagnosis requires lymphocyte subset analysis by flow cytometry to delineate risk for autoimmune and inflammatory (AI) disease, known as complicated CVID. In resource-limited settings, reduced access to flow cytometry limits CVID diagnostics. Objectives: We investigated the utility of serum cytokine testing, as compared to standard-of-care flow cytometry, for the diagnosis of AI disease in IEI and CVID. Methods: We performed a retrospective review of patients with Results: In IEI and CVID, higher sIL-2R and IL-10 levels correlated with more AI complications per patient and more severe T-cell immunophenotypes. Composite receiver-operating characteristic curves for sIL-2R and IL-10, as compared to lymphocyte subsets (naive CD4 Conclusions: sIL-2R and IL-10 testing had statistically comparable diagnostic performance for complicated CVID as compared to the current standard-of-care using flow cytometry.
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