ArticleBiochemistry and biophysics reports2025
Fibrinogen based resuscitation mitigates lung injury in mice with bacterial pneumonia after hemorrhagic shock.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Real-time prediction of trauma-induced coagulopathy using an inverted transformer (trauma-former): a methodological feasibility and simulation study based on the ADEMP framework.BMC medical research methodology · 2026Article
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3 authors.
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Abstract
While pneumonia is a common complication following severe trauma, the optimal treatment for this complication remains unclear. Our previous studies have shown that fibrinogen and fresh frozen plasma (FFP) administration have beneficial effects in mitigating lung dysfunction in mice after trauma and hemorrhagic shock (HS), due to the restoration of endothelial syndecan-1. The objective of the current study was to test these two therapeutics in a combined model of HS and pneumonia. We hypothesized they would be equally protective. C57BL/6 mice underwent HS [mean arterial pressure (MAP) of 40-45 mmHg for 1 h] and fluid resuscitation with lactated Ringer's (LR), fibrinogen concentrate (FIB, 5 mg/mouse in LR), and FFP all at 1x bled volume. Mice were then infected by P. aeruginosa [strain PA103, 3 × 10
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