Evidence map›Paper›PMID 40496859›Full record

ArticleFrontiers in immunology2025

mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney.

Daniel J Atwood, Zhibin He, Makoto Miyazaki, Katharina Hopp, Alkesh Jani, Seth B Furgeson, Sarah Faubel, Charles L Edelstein

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel J AtwoodRenal Division, Rocky Mountain Regional Veteran's Affairs (VA) Medical Center, Aurora, CO, United States.
Zhibin HeRenal Division, Rocky Mountain Regional Veteran's Affairs (VA) Medical Center, Aurora, CO, United States.
Makoto MiyazakiDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Katharina HoppDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Alkesh JaniRenal Division, Rocky Mountain Regional Veteran's Affairs (VA) Medical Center, Aurora, CO, United States.
Seth B FurgesonDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Sarah FaubelDivision of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Charles L EdelsteinRenal Division, Rocky Mountain Regional Veteran's Affairs (VA) Medical Center, Aurora, CO, United States.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
The role of MLKL in the regulation of vascular calcification in CKDR01HL132318 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAZAKI, MAKOTO · 2016 to 2025
$3.8M
The transcriptional control of vascular calcification in diseaseR01HL157064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Makoto Miyazaki · 2023 to 2026
$2.5M
A Novel Driver of Hyperphosphatemia and Vascular Calcification in CKDR01DK124901 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BLAINE, JUDITH T.,, MIYAZAKI, MAKOTO · 2021 to 2024
$1.9M
BLRD VA I01 BX003803NHLBI NIH HHS R01 HL132318NHLBI NIH HHS R01 HL157064NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK124901
6 · The paper itself

Abstract

Tertiary lymphoid tissues (TLTs) are ectopic lymphoid tissues that form

Indexed as

KidneyLymphoid TissuePolycystic Kidney DiseasesTOR Serine-Threonine KinasesAnimalsAutophagy-Related Protein 7Disease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutRegulatory-Associated Protein of mTORAtg7 protein, mouseAutophagy-Related Protein 7mTOR protein, mouseRegulatory-Associated Protein of mTORTOR Serine-Threonine KinasesautophagymTORp62polycystic kidneytertiary lymphoid tissue

Identifiers

PMID40496859
PMCPMC12148856

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.