Evidence map›Paper›PMID 40496846›Full record

ArticleResearch and practice in thrombosis and haemostasis2025

The role of factor V in trauma-induced coagulopathy: an observational and experimental study.

Pieter H Sloos, Romein W G Dujardin, Joost C M Meijers, Christine Gaarder, Ross Davenport, Simon Stanworth, Pär I Johansson, Jakob Stensballe, Marc Maegele, Nicole P Juffermans and 1 more

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Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pieter H SloosDepartment of Intensive Care Medicine, Amsterdam University Medical Center location University of Amsterdam, Amsterdam, the Netherlands.
Romein W G DujardinDepartment of Intensive Care Medicine, Amsterdam University Medical Center location University of Amsterdam, Amsterdam, the Netherlands.
Joost C M MeijersDepartment of Experimental Vascular Medicine, Amsterdam University Medical Center location University of Amsterdam, Amsterdam, the Netherlands.
Christine GaarderDepartment of Traumatology, Oslo University Hospital, Oslo, Norway.
Ross DavenportDepartment of Trauma Surgery, Barts and the London School of Medicine and Dentistry, London, United Kingdom.
Simon StanworthNational Health Service Blood and Transplant/Oxford University Hospital NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom.
Pär I JohanssonDepartment of Anesthesiology and Trauma Center, Center for Head and Orthopedics, Section for Transfusion Medicine, Copenhagen University Hospital Rigshospitalet, Capital Region Blood Bank, Copenhagen, Denmark.
Jakob StensballeDepartment of Anesthesiology and Trauma Center, Center for Head and Orthopedics, Section for Transfusion Medicine, Copenhagen University Hospital Rigshospitalet, Capital Region Blood Bank, Copenhagen, Denmark.
Marc MaegeleDepartment of Traumatology and Orthopedic Surgery, Cologne-Merheim Medical Center, University of Witten/Herdecke, Cologne, Germany.
Nicole P JuffermansAmsterdam Institute for Infection and Immunity, Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Center location University of Amsterdam, Amsterdam, the Netherlands.
Derek J B KleinveldDepartment of Intensive Care Medicine, Amsterdam University Medical Center location University of Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In bleeding patients with trauma-induced coagulopathy (TIC), factor (F)V becomes depleted, which may not be corrected with existing treatment strategies. It is currently unknown whether supplementing FV or FVa improves TIC. Objectives: To explore the relationship between FV activity and mortality in trauma patients, and to investigate the effect of FV(a) supplementation in addition to other treatment strategies in an Methods: The association between FV activity and mortality was studied using an international prospective cohort study of trauma patients. In an Results: A total of 1285 patients were included, with a median injury severity score of 16 (interquartile range: 8-26). Decreased FV activity was associated with increased mortality. In the whole blood TIC model, FVa increased maximum clot firmness and reduced fibrinolysis, both as a single and combination therapy. In the plasma TIC model, with lower tissue factor concentrations than in the whole blood model, FV(a) prolonged clotting times, both as a single treatment and in combination with other treatments. Conclusion: FV depletion after trauma is associated with increased mortality. In an

Indexed as

blood coagulation factorsfactor Vhemorrhagehemostasiswounds and Injuries

Identifiers

PMID40496846
PMCPMC12150085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.